malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication
| العنوان: | malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication |
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| المؤلفون: | Kaslow, DC, Okumu, F, Wells, TNC, Rabinovich, R, Bassat, Q, Birkett, A, Bompart, F, Burt, A, Chaccour, C, Chitnis, C, Culpepper, J, Domingo, G, Duffy, P, Ghani, A, Greenwood, B, Hall, BF, Hamon, N, Jacobs-Lorena, M, James, S, Koram, KA, Kremsner, P, Kumar, A, Leroy, D, Leroy, O, Lindsay, S, Majambere, S, Mbogo, C, McCarthy, J, Qi, G, Rasgon, J, Richardson, J, Richie, T, Sauerwein, R, Slutsker, L, Vekemans, J |
| المساهمون: | Bill & Melinda Gates Foundation, Medical Research Council (MRC) |
| المصدر: | Plos Medicine, 14, e1002455-e1002455 Plos Medicine, 14, 11, pp. e1002455-e1002455 PLoS Medicine, Vol 14, Iss 11, p e1002455 (2017) PLoS medicine, 2017, Vol.14(11), pp.e1002455 [Peer Reviewed Journal] Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname PLoS Medicine |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Plasmodium, GENE DRIVE SYSTEM, Biomedical Research, Mosquito Control, Computer science, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], law.invention, DOUBLE-BLIND, 0302 clinical medicine, law, Medicine and Health Sciences, HIGH-THROUGHPUT ASSAY, Protozoans, Vaccines, Collection Review, Vector control, Malarial Parasites, Eukaryota, Drugs, General Medicine, 11 Medical And Health Sciences, TRANSMISSION-BLOCKING ACTIVITY, Parasitic diseases, 3. Good health, Infectious Diseases, Transmission (mechanics), Malalties parasitàries, Risk analysis (engineering), Medicine, Malaria control, Life Sciences & Biomedicine, Drug Research and Development, Infectious Disease Control, RESISTANT ANOPHELES-GAMBIAE, 030231 tropical medicine, Severe disease, Malària, Antimalarials, 03 medical and health sciences, Medicine, General & Internal, All institutes and research themes of the Radboud University Medical Center, Malaria elimination, General & Internal Medicine, Malaria Vaccines, Parasite Groups, Parasitic Diseases, medicine, Animals, Humans, Disease Eradication, VIVAX INFECTION, Pharmacology, Science & Technology, NUCLEIC-ACID AMPLIFICATION, Organisms, Biology and Life Sciences, PLASMODIUM-FALCIPARUM MALARIA, PYRIPROXYFEN MIXTURE NET, Tropical Diseases, medicine.disease, Parasitic Protozoans, Insect Vectors, Malaria, 030104 developmental biology, Direct Treatment, Insecticide resistance, BLOOD-STAGE MALARIA, Parasitology, Apicomplexa |
| الوصف: | Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control. These advances have once again put malaria elimination on the agenda. However, it is clear that even with the means available today, malaria control and elimination pose a formidable challenge in many settings. Thus, currently available resources must be used more effectively, and new products and approaches likely to achieve these goals must be developed. This paper considers tools (both those available and others that may be required) to achieve and maintain malaria elimination. New diagnostics are needed to direct treatment and detect transmission potential; new drugs and vaccines to overcome existing resistance and protect against clinical and severe disease, as well as block transmission and prevent relapses; and new vector control measures to overcome insecticide resistance and more powerfully interrupt transmission. It is also essential that strategies for combining new and existing approaches are developed for different settings to maximise their longevity and effectiveness in areas with continuing transmission and receptivity. For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. This becomes increasingly important as more countries move towards elimination. David Kaslow and colleagues examine the progress in reasearch for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication and propose a research agenda. |
| وصف الملف: | application/pdf |
| تدمد: | 1549-1277 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d1d5666de448caa2e76c0c05dd82ce https://doi.org/10.1371/journal.pmed.1002455 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....14d1d5666de448caa2e76c0c05dd82ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15491277 |
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