The impact of preimplantation genetic testing on first- and second-trimester maternal serum analyte levels
| العنوان: | The impact of preimplantation genetic testing on first- and second-trimester maternal serum analyte levels |
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| المؤلفون: | Moti Gulersen, David Krantz, Xueying Li, Alexandra Peyser, Randi Goldman, Christine Mullin, Eran Bornstein, Burton Rochelson |
| المصدر: | The Journal of Maternal-Fetal & Neonatal Medicine. 35:10435-10443 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology |
| الوصف: | To determine whether preimplantation genetic testing (PGT) is associated with a change in maternal serum analyte levels in pregnancies conceived viaRetrospective cohort of singleton and twin IVF pregnancies with available first- or second-trimester serum analyte data from 01/2014 to 09/2019. Multiple of the median (MoM) values for free β-human chorionic gonadotropin (β-hCG), pregnancy-associated plasma protein A (PAPP-A), alpha-fetoprotein (AFP), inhibin A, and unconjugated estriol, were compared between two groups: pregnancies conceived after transfer of PGT screened euploid embryos vs. those conceived after transfer of untested embryos. Multiple linear regression of log MoM values withNine hundred and sixty-two singleton and 165 twin IVF pregnancies with serum analyte data available for analysis were included. PGT was associated with a higher median first- and second-trimester AFP compared to no PGT in singletons (1.23 MoM vs. 1.13 MoM; parameter estimate [PE] 1.08, 95% CI 1.00-1.17,Our data suggest that PGT is associated with higher maternal serum levels of second-trimester AFP in singleton and lower levels of first-trimester PAPP-A in twin pregnancies conceived via IVF. |
| تدمد: | 1476-4954 1476-7058 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e87ba0671a1624bf44f111b7e5473d https://doi.org/10.1080/14767058.2022.2128661 |
| رقم الأكسشن: | edsair.doi.dedup.....14e87ba0671a1624bf44f111b7e5473d |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14764954 14767058 |
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