Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011
| العنوان: | Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 |
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| المؤلفون: | Laura Arbour, Padma Surmala, Cheryl R. Greenberg, Sharon Edmunds-Potvin, Sorcha A. Collins, Laakkuluk Williamson Bathory, Geraldine Osborne |
| المساهمون: | University of Manitoba |
| المصدر: | BMC Pediatrics, Vol 12, Iss 1, p 190 (2012) BMC Pediatrics |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Genetic Markers, Pediatrics, medicine.medical_specialty, Sudden infant death syndrome, Population, Nunavut, Infant mortality, Infections, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Cause of Death, 030225 pediatrics, medicine, Humans, Pediatrics, Perinatology, and Child Health, 030212 general & internal medicine, Inuit population, education, Aboriginal, Retrospective Studies, Cause of death, High rate, education.field_of_study, Carnitine O-Palmitoyltransferase, Carnitine palmitoyltransferase 1 deficiency, CPT1A P479L variant, business.industry, Infant Care, Infant, Newborn, lcsh:RJ1-570, Infant, lcsh:Pediatrics, 3. Good health, Inuit, Pediatrics, Perinatology and Child Health, Sudden unexpected death in infancy, National average, business, Infant, Premature, Sudden Infant Death, Research Article, Demography |
| الوصف: | Background The northern territory Nunavut has Canada’s largest jurisdictional land mass with 33,322 inhabitants, of which 85% self-identify as Inuit. Nunavut has rates of infant mortality, postneonatal mortality and hospitalisation of infants for respiratory infections that greatly exceed those for the rest of Canada. The infant mortality rate in Nunavut is 3 times the national average, and twice that of the neighbouring territory, the Northwest Territories. Nunavut has the largest Inuit population in Canada, a population which has been identified as having high rates of Sudden Infant Death Syndrome (SIDS) and infant deaths due to infections. Methods To determine the causes and potential risk factors of infant mortality in Nunavut, we reviewed all infant deaths ( Results Sudden death in infancy (SIDS/SUDI; 48%) and infection (21%) were the leading causes of infant death, with rates significantly higher than for Canada (2003–2007). Of SIDS/SUDI cases with information on sleep position (n=42) and bed-sharing (n=47), 29 (69%) were sleeping non-supine and 33 (70%) were bed-sharing. Of those bed-sharing, 23 (70%) had two or more additional risk factors present, usually non-supine sleep position. CPT1A P479L homozygosity, which has been previously associated with infant mortality in Alaska Native and British Columbia First Nations populations, was associated with unexpected infant death (SIDS/SUDI, infection) throughout Nunavut (OR:3.43, 95% CI:1.30-11.47). Conclusion Unexpected infant deaths comprise the majority of infant deaths in Nunavut. Although the CPT1A P479L variant was associated with unexpected infant death in Nunavut as a whole, the association was less apparent when population stratification was considered. Strategies to promote safe sleep practices and further understand other potential risk factors for infant mortality (P479L variant, respiratory illness) are underway with local partners. |
| وصف الملف: | text/xml; application/pdf |
| تدمد: | 1471-2431 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14eb1c1cd825519d264de8b84ae32e48 https://doi.org/10.1186/1471-2431-12-190 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....14eb1c1cd825519d264de8b84ae32e48 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712431 |
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