The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors
| العنوان: | The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors |
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| المؤلفون: | Douglas Forrest, John Chan, Björn Vennström, Tammy L. Dellovade, Donald W. Pfaff |
| المصدر: | Nature Neuroscience. 3:472-475 |
| بيانات النشر: | Springer Science and Business Media LLC, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Vasopressins, medicine.drug_class, Posture, Mice, Inbred Strains, Biology, Oxytocin, Thyroid hormone receptor beta, Mice, Sexual Behavior, Animal, Internal medicine, medicine, Animals, Progesterone, Mice, Knockout, Receptors, Thyroid Hormone, Triiodothyronine, Thyroid hormone receptor, Estradiol, General Neuroscience, Body Weight, Uterus, Estrogens, Organ Size, Sex hormone receptor, Preoptic Area, Thyroxine, Endocrinology, Receptors, Estrogen, Thyroid hormone receptor alpha, Estrogen, Hormone receptor, Female, Gene Deletion, Paraventricular Hypothalamic Nucleus, Hormone |
| الوصف: | The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TRalpha 1 reduced them, whereas deletion of TRbeta actually increased them. These results could not be attributed to altered levels of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences. |
| تدمد: | 1546-1726 1097-6256 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f8d8f73a799c41e75335b514644b90 https://doi.org/10.1038/74846 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....14f8d8f73a799c41e75335b514644b90 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461726 10976256 |
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