A dietary anthocyanin cyanidin-3-O-glucoside binds to PPARs to regulate glucose metabolism and insulin sensitivity in mice
| العنوان: | A dietary anthocyanin cyanidin-3-O-glucoside binds to PPARs to regulate glucose metabolism and insulin sensitivity in mice |
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| المؤلفون: | Seung Ok Yang, Hyun Seok Oh, Young Suk Kim, Yeonji Kim, Bobae Kim, Min Young So, Ji Hae Lee, Ye Eun Yoon, Chunyan Wu, Tai Hyun Park, Mi Young Jeong, Ji-Sun Kim, Sung Joon Lee, Yaoyao Jia, Jia Kim, Soyoung Lee, Trung Thanh Thach |
| المصدر: | Communications Biology Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Glucose uptake, Metabolite, Peroxisome Proliferator-Activated Receptors, Medicine (miscellaneous), 030209 endocrinology & metabolism, Carbohydrate metabolism, Article, General Biochemistry, Genetics and Molecular Biology, Anthocyanins, Fats, Mediator Complex Subunit 1, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oral administration, Internal medicine, Ketogenesis, medicine, Animals, Humans, Insulin, lcsh:QH301-705.5, Beta oxidation, Chemistry, food and beverages, Agriculture, Hep G2 Cells, Lipid Metabolism, Ligand (biochemistry), Metabolic syndrome, Glucose, 030104 developmental biology, Endocrinology, lcsh:Biology (General), Liver, Anthocyanin, Dietary Supplements, Insulin Resistance, Energy Metabolism, General Agricultural and Biological Sciences, Biomedical materials |
| الوصف: | We demonstrate the mechanism by which C3G, a major dietary anthocyanin, regulates energy metabolism and insulin sensitivity. Oral administration of C3G reduced hepatic and plasma triglyceride levels, adiposity, and improved glucose tolerance in mice fed high-fat diet. Hepatic metabolomic analysis revealed that C3G shifted metabolite profiles towards fatty acid oxidation and ketogenesis. C3G increased glucose uptake in HepG2 cells and C2C12 myotubes and induced the rate of hepatic fatty acid oxidation. C3G directly interacted with and activated PPARs, with the highest affinity for PPARα. The ability of C3G to reduce plasma and hepatic triglycerides, glucose tolerance, and adiposity and to induce oxygen consumption and energy expenditure was abrogated in PPARα-deficient mice, suggesting that PPARα is the major target for C3G. These findings demonstrate that the dietary anthocyanin C3G activates PPARs, a master regulators of energy metabolism. C3G is an agonistic ligand of PPARs and stimulates fuel preference to fat. Jia, Wu, Kim et al. show that cyanidin-3-O-glucoside (C3G), a major dietary anthocyanin, functions as a ligand for PPARalpha to regulate energy metabolism and insulin sensitivity in mouse models of obesity and diabetes. This study suggests that C3G slows down the metabolism of glucose, making it a promising therapeutic agent. |
| تدمد: | 2399-3642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15135d0725ed85e2afc2bae701f6bb4d https://doi.org/10.1038/s42003-020-01231-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....15135d0725ed85e2afc2bae701f6bb4d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23993642 |
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