The MID1 protein
| العنوان: | The MID1 protein |
|---|---|
| المؤلفون: | Annika Heinz, Judith Schilling, Willeke van Roon-Mom, Sybille Krauß |
| المصدر: | Frontiers in Genetics, 12. FRONTIERS MEDIA SA Frontiers in Genetics Frontiers in genetics 12, 761714 (2021). doi:10.3389/fgene.2021.761714 Frontiers in Genetics, Vol 12 (2021) |
| بيانات النشر: | FRONTIERS MEDIA SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | CAG repeat, congenital, hereditary, and neonatal diseases and abnormalities, Translation, mRNA translation, RNA-protein interaction, Messenger-RNS, MID1, Alzheimerkrankheit, Huntington-Chorea, Huntington's disease, QH426-470, Alzheimer's disease, nervous system diseases, RNA-targeting drug, nervous system, ddc:570, Perspective, mental disorders, Genetics, Molecular Medicine, Alzheimer’s disease, Genetics (clinical), Huntington’s disease, 570 Biowissenschaften, Biologie |
| الوصف: | Huntington’s disease (HD) is caused by an expansion mutation of a CAG repeat in exon 1 of the huntingtin (HTT) gene, that encodes an expanded polyglutamine tract in the HTT protein. HD is characterized by progressive psychiatric and cognitive symptoms associated with a progressive movement disorder. HTT is ubiquitously expressed, but the pathological changes caused by the mutation are most prominent in the central nervous system. Since the mutation was discovered, research has mainly focused on the mutant HTT protein. But what if the polyglutamine protein is not the only cause of the neurotoxicity? Recent studies show that the mutant RNA transcript is also involved in cellular dysfunction. Here we discuss the abnormal interaction of the mutant HTT transcript with a protein complex containing the MID1 protein. MID1 aberrantly binds to CAG repeats and this binding increases with CAG repeat length. Since MID1 is a translation regulator, association of the MID1 complex stimulates translation of mutant HTT mRNA, resulting in an overproduction of polyglutamine protein. Thus, blocking the interaction between MID1 and mutant HTT mRNA is a promising therapeutic approach. Additionally, we show that MID1 expression in the brain of both HD patients and HD mice is aberrantly increased. This finding further supports the concept of blocking the interaction between MID1 and mutant HTT mRNA to counteract mutant HTT translation as a valuable therapeutic strategy. In line, recent studies in which either compounds affecting the assembly of the MID1 complex or molecules targeting HTT RNA, show promising results. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1538fee08ae4aa18d88f6d005bb49faf https://hdl.handle.net/1887/3256612 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1538fee08ae4aa18d88f6d005bb49faf |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |