Stress, cortisol, and B lymphocytes: a novel approach to understanding academic stress and immune function
| العنوان: | Stress, cortisol, and B lymphocytes: a novel approach to understanding academic stress and immune function |
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| المؤلفون: | Bonnie A. McGregor, Denise L Albano, Karly M. Murphy, Rachel M. Ceballos |
| المصدر: | Stress. 19:185-191 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Hydrocortisone, Physiology, Lymphocyte, Student Status, Article, Young Adult, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Immune system, Stress (linguistics), Humans, Medicine, Saliva, Students, Psychiatry, Salivary cortisol, B-Lymphocytes, Depression, Endocrine and Autonomic Systems, business.industry, Psychiatry and Mental health, Distress, 030104 developmental biology, Neuropsychology and Physiological Psychology, medicine.anatomical_structure, Graduate students, Female, Seasons, Bone marrow, business, Stress, Psychological, 030217 neurology & neurosurgery |
| الوصف: | Animal and human in vitro models suggest that stress-related B lymphocyte decrements are due to high levels of glucocorticoids which cause apoptosis of pre-B-cells as they emerge from the bone marrow. The present study sought to explore the relationships among distress, salivary cortisol, and human B lymphocytes in vivo. Distress (perceived stress, negative affect, depressive symptoms), lymphocyte phenotype, and salivary cortisol were assessed among first-year graduate students (n = 22) and a community control sample (n = 30) at the start of classes in the fall and the week immediately before spring preliminary exams. Compared to controls, students reported greater distress on all measures at each time point except baseline perceived stress. Hierarchical linear regression with necessary control variables was used to assess the effect of student status on the three measures of distress, the four measures of lymphocyte phenotype, and cortisol AUC and CAR over time (T1-T2). Student status was associated with a significant decrease in CD19 + B lymphocytes and flattened cortisol awakening response (CAR). Change in CAR was associated with the decrease in CD19 + B lymphocytes. Results indicated that there are significant associations among student status, flattening of CAR, and decrements in CD19 + lymphocytes. |
| تدمد: | 1607-8888 1025-3890 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1578777b0e1c642e9e9f75a780e4a6ef https://doi.org/10.3109/10253890.2015.1127913 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1578777b0e1c642e9e9f75a780e4a6ef |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 16078888 10253890 |
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