Suppression by Interleukin 4 of Activation of Human Blood Monocytes to the Tumoricidal State
| العنوان: | Suppression by Interleukin 4 of Activation of Human Blood Monocytes to the Tumoricidal State |
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| المؤلفون: | Akio Okubo, Takeshi Ogura, Saburo Sone, Yasuhiko Nishioka |
| المصدر: | Japanese Journal of Cancer Research : Gann |
| بيانات النشر: | Blackwell Publishing Ltd, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Cytotoxicity, Immunologic, Lipopolysaccharides, Cancer Research, Time Factors, Lipopolysaccharide, medicine.medical_treatment, Biology, In Vitro Techniques, Monocyte, Article, Monocytes, Interleukin 4, chemistry.chemical_compound, In vivo, medicine, Tumor Cells, Cultured, Humans, Melanoma, Cells, Cultured, Immunity, Cellular, Dose-Response Relationship, Drug, Tumor Necrosis Factor-alpha, Molecular biology, medicine.anatomical_structure, Cytokine, Oncology, chemistry, Immunology, Tumor cytotoxicity, Interleukin 19, Tumor necrosis factor alpha, Interleukin-4, Muramyl dipeptide, Interleukin-1 |
| الوصف: | The effect of interleukin 4 (IL-4) on expression of antitumor activity of blood monocytes purified by counter-flow centrifugal elutriation from healthy donors was examined. The blood monocytes were incubated for 24 h in medium with lipopolysaccharide, interferon gamma (IFN-gamma) or desmethyl muramyl dipeptide (norMDP) or with IFN-gamma and norMDP in the presence of IL-4, and then their tumoricidal activity was assayed by measuring 125IUdR release from human melanoma (A375) cells. Irrespective of activation stimulus, addition of IL-4 to cultures of monocytes and activators resulted in dose-dependent suppression of the tumoricidal activity of monocytes against parent A375 melanoma cells and the variant cells, A375-R resistant to IL-1 and tumor necrosis factor alpha. IL-4 suppressed the early induction phase of monocyte activation. Rabbit anti-IL-4 antisera completely blocked the IL-4-mediated suppression of monocyte activation to the tumoricidal state. These findings suggest that IL-4 is important in vivo in down-regulation of anti-tumor expression of monocytes. |
| اللغة: | English |
| تدمد: | 1876-4673 0910-5050 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157d1bed78234fad9096c565e9d67a55 http://europepmc.org/articles/PMC5918117 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....157d1bed78234fad9096c565e9d67a55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18764673 09105050 |
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