Ureteral stent technology: Drug-eluting stents and stent coatings

التفاصيل البيبلوغرافية
العنوان: Ureteral stent technology: Drug-eluting stents and stent coatings
المؤلفون: Peter A. Cadieux, John D. Denstedt, Samantha A. Whiteside, Luo Yang
المصدر: Asian Journal of Urology, Vol 2, Iss 4, Pp 194-201 (2015)
Asian Journal of Urology
بيانات النشر: Elsevier BV, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Drug, medicine.medical_specialty, Recurrent infections, Urinary infection, Stent coatings, business.industry, Urinary retention, Urinary system, media_common.quotation_subject, medicine.medical_treatment, Stent, Ureteral stents, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, Article, Surgery, surgical procedures, operative, Stent removal, medicine, medicine.symptom, business, Drug-eluting stents, media_common
الوصف: Ureteral stents are commonly used following urological procedures to maintain ureteral patency. However, alongside the benefits of the device, indwelling stents frequently cause significant patient discomfort (pain, urgency, frequency) and can become encrusted and infected. The importance of these sequelae is that they are not only bothersome to the patient but can lead to significant morbidity, urinary retention, ureteral damage, recurrent infections, pyelonephritis and sepsis. When these problems occur, stent removal or replacement alongside antibiotic, analgesic and/or other symptom-modifying therapies are essential to successfully treat the patient. In an attempt to prevent such morbidity, numerous approaches have been investigated over the past several decades to modify the stent itself, thereby affecting changes locally within the urinary tract without significant systemic therapy. These strategies include changes to device design, polymeric composition, drug-elution and surface coatings. Of these, drug-elution and surface coatings are the most studied and display the most promise for advancing ureteral stent use and efficacy. This article reviews these two strategies in detail to determine their clinical potential and guide future research in the area.
تدمد: 2214-3882
DOI: 10.1016/j.ajur.2015.08.006
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159dc215fce126fde99a576da06a36b2
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....159dc215fce126fde99a576da06a36b2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:22143882
DOI:10.1016/j.ajur.2015.08.006