Factors related to antibiotic-associated diarrhea in patients in the intensive care unit receiving antifungals: a single-center retrospective study
| العنوان: | Factors related to antibiotic-associated diarrhea in patients in the intensive care unit receiving antifungals: a single-center retrospective study |
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| المؤلفون: | Wang Xue, Zhang Lei, Shi Qindong, He Yingli, Guo Litao, Zhang Yanshu, Sun Jingjing, Liu Yu |
| المصدر: | Journal of International Medical Research, Vol 47 (2019) The Journal of International Medical Research |
| بيانات النشر: | SAGE Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Diarrhea, Male, medicine.medical_specialty, Medicine (General), Antifungal Agents, Clinical Research Reports, medicine.drug_class, Critical Illness, enzyme inhibitors, Antibiotics, Single Center, intensive care unit, Biochemistry, antibiotics, azithromycins, law.invention, 03 medical and health sciences, 0302 clinical medicine, R5-920, Risk Factors, law, Humans, Medicine, In patient, 030212 general & internal medicine, Retrospective Studies, business.industry, Biochemistry (medical), Retrospective cohort study, Cell Biology, General Medicine, Middle Aged, Prognosis, Intensive care unit, Anti-Bacterial Agents, Intensive Care Units, Multivariate Analysis, Emergency medicine, Regression Analysis, Female, 030211 gastroenterology & hepatology, proton pump inhibitors, Antibiotic-associated diarrhea, medicine.symptom, business, antifungals |
| الوصف: | Objective To analyze factors related to antibiotic-associated diarrhea (AAD) in patients in the intensive care unit (ICU) receiving antifungals with the aim of informing rational antibiotic use. Methods Sex, age, medical history, use of proton pump inhibitors, administration of parenteral nutrition, albumin level, occurrence of AAD, type of antibiotics, duration of ICU admission, and prognosis were retrospectively analyzed. The associations of age, sex, medical history, and other factors with AAD were associated by logistic regression. Results In total, 284 patients were enrolled (antifungals, n = 110; no antifungals, n = 174). The total incidence of AAD was 32.39%. The incidence of AAD was significantly different between the groups (52.73% vs. 19.54%). The duration of proton pump inhibitor therapy, duration of antifungal therapy, enzyme inhibitor antibiotic use, and azithromycin use were associated with AAD in ICU patients receiving antifungal therapy. The mean duration of ICU admission was higher in patients receiving antifungal therapy (20.14 ± 11.50 vs. 14.48 ± 8.54 days). There was no significant difference in ICU mortality rates. Conclusion The duration of proton pump inhibitor therapy, duration of antifungal therapy, use of enzyme inhibitor antibiotics, and use of azithromycins were associated with AAD in ICU patients receiving antifungal therapy. |
| اللغة: | English |
| تدمد: | 1473-2300 0300-0605 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c57fa385ecc08f1bef5ed605c091c6 https://doaj.org/article/400305be350e4177a6604ae7ee85ca19 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....15c57fa385ecc08f1bef5ed605c091c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
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