Antiproliferative activity and apoptosis induction, of organo-antimony(III)–copper(I) conjugates, against human breast cancer cells
العنوان: | Antiproliferative activity and apoptosis induction, of organo-antimony(III)–copper(I) conjugates, against human breast cancer cells |
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المؤلفون: | Banti, C. N., Tsiatouras, V., Karanicolas, K., Panagiotou, N., Tasiopoulos, Anastasios J., Kourkoumelis, N., Hadjikakou, S. K. |
المساهمون: | Tasiopoulos, Anastasios J. [0000-0002-4804-3822], Kourkoumelis, N. [0000-0003-3264-2406], Banti, C. N. [0000-0001-6727-2711], Hadjikakou, S. K. [0000-0001-9556-6266] |
المصدر: | Molecular Diversity Mol Divers |
بيانات النشر: | Springer Science and Business Media LLC, 2019. |
سنة النشر: | 2019 |
مصطلحات موضوعية: | Antimony, Programmed cell death, Cell cycle checkpoint, Antineoplastic Agents, Apoptosis, Breast Neoplasms, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Catalysis, Cell Line, Inorganic Chemistry, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Humans, Physical and Theoretical Chemistry, Fibroblast, Molecular Biology, Cell Proliferation, Cell Death, 010405 organic chemistry, Chemistry, Organic Chemistry, Cell Cycle Checkpoints, General Medicine, Fibroblasts, Molecular biology, In vitro, 0104 chemical sciences, medicine.anatomical_structure, Docking (molecular), Cancer cell, MCF-7 Cells, Female, Copper, Genotoxicity, DNA, Information Systems |
الوصف: | Three known organo-antimony(III)–copper(I), mixed-metal small bioactive molecules (SBAMs) of formula [Cu(tpSb)3Cl] (1), [Cu2(tpSb)4Br2] (2) and [Cu2(tpSb)4I2] (3) (tpSb = triphenylstibine) were used for the clarification of their antiproliferative activity against human breast cancer cells: MCF-7 (hormone-dependent cells) and MDA-MB-231 (hormone-independent cells). The in vitro toxicity of 1–3 was studied against normal human foetal lung fibroblast cells (MRC-5). The genotoxicity of 1–3 was determined by the presence of micronucleus. The type of the cell death caused by 1–3 was determined using cell cycle arrest. The molecular mechanism of action of 1–3 was defined by their binding affinity towards CT-DNA (calf thymus DNA) using UV spectroscopy and viscosity measurements. Docking studies depict the interactions between 1–3 and DNA. Computations were also employed in order to rationalize the activity of these compounds. This is based on the contribution of metal aromaticity in the case of compounds 2 and 3 where the short Cu···Cu distance (2.7724(6) (2) and 2.7251(11) (3) Ǻ, respectively) suggests d10–d10 interaction between metal centres. The known small bioactive molecules of formula [Cu(tpSb)3Cl] (1), [Cu2(tpSb)4Br2] (2) and [Cu2(tpSb)4I2] (3) (tpSb = triphenylstibine) were used for the clarification of their antiproliferative activity against human breast cancer cells: MCF-7 (hormone-dependent (HD) cells) and MDA-MB-231 (hormone-independent (HI) cells). |
تدمد: | 1573-501X 1381-1991 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e398cb805571e930281a6406d1245c https://doi.org/10.1007/s11030-019-10014-z |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....15e398cb805571e930281a6406d1245c |
قاعدة البيانات: | OpenAIRE |
تدمد: | 1573501X 13811991 |
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