Effects of 1p/19q Codeletion on Immune Phenotype in Low Grade Glioma
| العنوان: | Effects of 1p/19q Codeletion on Immune Phenotype in Low Grade Glioma |
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| المؤلفون: | Qinqin Wei, Yujia Zhao, Lei Lv, Ye Zhao, Qiyi Yi, Yuliu Zhang |
| المصدر: | Frontiers in Cellular Neuroscience Frontiers in Cellular Neuroscience, Vol 15 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Chemokine, immune checkpoint genes, Neurosciences. Biological psychiatry. Neuropsychiatry, 1p/19q Codeletion, medicine.disease_cause, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Immune system, Glioma, medicine, Gene, Original Research, Mutation, tumor immune microenvironment, low-grade glioma, biology, 1p/19q codeletion, biochemical phenomena, metabolism, and nutrition, medicine.disease, IDH mutation, Immune checkpoint, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cellular Neuroscience, Cancer research, biology.protein, bacteria, tumor immune cell infiltration, RC321-571 |
| الوصف: | Background:Chromosome 1p/19q codeletion is one of the most important genetic alterations for low grade gliomas (LGGs), and patients with 1p/19q codeletion have significantly prolonged survival compared to those without the codeletion. And the tumor immune microenvironment also plays a vital role in the tumor progression and prognosis. However, the effect of 1p/19q codeletion on the tumor immune microenvironment in LGGs is unclear.Methods:Immune cell infiltration of 281 LGGs from The Cancer Genome Atlas (TCGA) and 543 LGGs from the Chinese Glioma Genome Atlas (CGGA) were analyzed for immune cell infiltration through three bioinformatics tools: ESTIMATE algorithm, TIMER, and xCell. The infiltrating level of immune cells and expression of immune checkpoint genes were compared between different groups classified by 1p/19q codeletion and IDH (isocitrate dehydrogenase) mutation status. The differential biological processes and signaling pathways were evaluated through Gene Set Enrichment Analysis (GSEA). Correlations were analyzed using Spearman correlation.Results:1p/19q codeletion was associated with immune-related biological processes in LGGs. The infiltrating level of multiple kinds of immune cells and expression of immune checkpoint genes were significantly lower in 1p/19q codeletion LGGs compared to 1p/19q non-codeletion cohorts. There are 127 immune-related genes on chromosome 1p or 19q, such as TGFB1, JAK1, and CSF1. The mRNA expression of these genes was positively correlated with their DNA copy number. These genes are distributed in multiple immune categories, such as chemokines/cytokines, TGF-β family members, and TNF family members, regulating immune cell infiltration and expression of the immune checkpoint genes in tumors.Conclusion:Our results indicated that 1p/19q codeletion status is closely associated with the immunosuppressive microenvironment in LGGs. LGGs with 1p/19q codeletion display less immune cell infiltration and lower expression of immune checkpoint genes than 1p/19q non-codeletion cases. Mechanistically, this may be, at least in part, due to the deletion of copy number of immune-related genes in LGGs with 1p/19q codeletion. Our findings may be relevant to investigate immune evasion in LGGs and contribute to the design of immunotherapeutic strategies for patients with LGGs. |
| تدمد: | 1662-5102 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162046de2c376de79843ac91a2bc5934 https://pubmed.ncbi.nlm.nih.gov/34335194 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....162046de2c376de79843ac91a2bc5934 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16625102 |
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