Biological Investigations and Spectroscopic Studies of New Moxifloxacin/Glycine‐Metal Complexes
| العنوان: | Biological Investigations and Spectroscopic Studies of New Moxifloxacin/Glycine‐Metal Complexes |
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| المؤلفون: | Hazem S. Elshafie, Ippolito Natale Camele, Shimaa H. Sakr, Sadeek A. Sadeek |
| المصدر: | Chemistry & Biodiversity. 16:e1800633 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Erythrocytes, Magnetic Resonance Spectroscopy, DPPH, Metal ions in aqueous solution, Moxifloxacin, Glycine, Bioengineering, 01 natural sciences, Biochemistry, Antioxidants, Lepidium sativum, Raphanus, Metal, chemistry.chemical_compound, Picrates, Coordination Complexes, Humans, Chelation, Benzothiazoles, Molecular Biology, ABTS, Molecular Structure, 010405 organic chemistry, Chemistry, Biphenyl Compounds, Cell Membrane, Biological activity, General Chemistry, General Medicine, Antimicrobial, 0104 chemical sciences, Zinc, 010404 medicinal & biomolecular chemistry, Tin, visual_art, visual_art.visual_art_medium, Molecular Medicine, Spectrophotometry, Ultraviolet, Sulfonic Acids, Nuclear chemistry |
| الوصف: | Two novel ligand-metal complexes were prepared through the reaction of Zn(II) and Sn(II) with moxifloxacin (MOX) in the presence of glycine (Gly) to investigate their biological activities. IR, UV/VIS and 1 H-NMR analysis have been carried out for insuring the chelation process. Results suggested that MOX and Gly react with the metal ions through the carbonyl oxygen atom and the oxygen atom of the carboxylic group of MOX and Gly. The antimicrobial activity was carried out against some common bacterial and fungal pathogens and the radical scavenging activity (RSA%) was evaluated using DPPH and ABTS methods. Phytotoxic effect of the prepared complexes was evaluated in vitro against Raphanus raphanistrum and Lepidium sativum. Hemolytic activity was tested against cell membrane of erythrocytes. Results showed that the two prepared complexes exhibited high antimicrobial activity against all tested phytopathogens and no significant phytotoxic effect has been observed. Only MOX-Zn(II) complex showed moderate hemolysis at 100 % concentration. |
| تدمد: | 1612-1880 1612-1872 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169c199b560cdd3586a8d36d891d07fe https://doi.org/10.1002/cbdv.201800633 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....169c199b560cdd3586a8d36d891d07fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16121880 16121872 |
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