Study of the Antimicrobial Effect of an Ethanolic Extract of Propolis in Periodontal Disease
| العنوان: | Study of the Antimicrobial Effect of an Ethanolic Extract of Propolis in Periodontal Disease |
|---|---|
| المؤلفون: | Esther Muñoz-Soto, Candela Reyes-Botella, Maria Victoria Olmedo-Gaya, Javier Díaz-Castro, Maria Jesús Lisbona-González, Jorge Moreno-Fernandez |
| المساهمون: | [Lisbona-González,MJ, Muñoz-Soto,E, Reyes-Botella,C, Olmedo-Gaya,MV] Department of Stomatology, School of Dentistry, University of Granada, Granada, Spain. [Diaz-Castro,J, Moreno-Fernandez,J] Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, Granada, Spain. [Diaz-Castro,J, Moreno-Fernandez,J] Institute of Nutrition and Food Technology 'José Mataix Verdú', University of Granada, Granada, Spain. [Diaz-Castro,J] nstituto de Investigación Biosanitaria (IBS), Granada, Spain., [Jesus Lisbona-Gonzalez, Maria] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Munoz-Soto, Esther] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Reyes-Botella, Candela] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Victoria Olmedo-Gaya, Maria] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Diaz-Castro, Javier] Univ Granada, Fac Pharm, Dept Physiol, Campus Univ Cartuja, Granada 18071, Spain, [Moreno-Fernandez, Jorge] Univ Granada, Fac Pharm, Dept Physiol, Campus Univ Cartuja, Granada 18071, Spain, [Diaz-Castro, Javier] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Granada 18071, Spain, [Moreno-Fernandez, Jorge] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Granada 18071, Spain, [Diaz-Castro, Javier] Inst Invest Biosanitaria IBS, Granada 18016, Spain, University of Granada, doctoral program in clinical medicine and public health |
| المصدر: | Applied Sciences, Vol 11, Iss 7463, p 7463 (2021) Digibug. Repositorio Institucional de la Universidad de Granada instname Applied Sciences Volume 11 Issue 16 |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Infección persistente, Technology, oral healing, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Bacteriological Techniques::Bacterial Load [Medical Subject Headings], periodontal disease, Gastroenterology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Gingivitis, Scaling and root planing, Própolis, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Dentistry::Periodontics::Dental Prophylaxis::Dental Scaling::Root Planing [Medical Subject Headings], General Materials Science, Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::Gingival Diseases::Gingivitis [Medical Subject Headings], Biology (General), Antiinfecciosos, Instrumentation, Adjuvant, Plaque, Fluid Flow and Transfer Processes, Organisms::Bacteria::Bacteroidetes::Bacteroidaceae::Prevotella::Prevotella intermedia [Medical Subject Headings], biology, Physics, General Engineering, Prevotella intermedia, Treponema denticola, Periodontitis crónica, Engineering (General). Civil engineering (General), Computer Science Applications, propolis, Chemistry, Antimicrobial effect, medicine.symptom, TA1-2040, Periodontal disease, medicine.medical_specialty, QH301-705.5, QC1-999, Bleeding on probing, Antimicrobial effectiveness, Chemicals and Drugs::Biological Factors::Antigens::Antigens, Bacterial::Tuberculin [Medical Subject Headings], Propolis, Grupos control, Organisms::Bacteria::Bacteroidetes::Bacteroidaceae::Porphyromonas::Porphyromonas gingivalis [Medical Subject Headings], Internal medicine, antimicrobial effect, medicine, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Porphyromonas gingivalis, QD1-999, Periodontitis, Capacity, business.industry, Process Chemistry and Technology, biology.organism_classification, medicine.disease, Chronic periodontitis, Oral healing, Enfermedades periodontales, business, Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Anaerobic Bacteria::Gram-Negative Anaerobic Straight, Curved, and Helical Rods::Spirochaetaceae::Treponema::Treponema denticola [Medical Subject Headings], Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::Periodontitis::Chronic Periodontitis [Medical Subject Headings], Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Resins, Plant::Propolis [Medical Subject Headings] |
| الوصف: | Periodontal disease encompasses gingivitis and periodontitis and is one of the most common chronic infections in the adult population. This study aimed to evaluate the influence of Spanish propolis extract (EEP) on the effect of the clinical and microbiological parameters as an adjuvant to scaling and root planning in patients undergoing supportive periodontal therapy (SPT). Forty chronic periodontitis patients were randomly assigned into two groups for the treatment. In the control group (n = 20), the sites were treated by scaling and root planing followed by gingival irrigation with physiological saline and in the test group (n = 20), the sites were treated by scaling and root planing followed by subgingival placement of EEP. At baseline (BL), bleeding on probing positive (BOP+) sites with probing pocket (PPD) ≥ 4 mm were defined as study sites. Plaque index, PPD, BOP, clinical attachment level (CAL), and subgingival plaque were evaluated at BL and 1 month later. The results showed a significant clinical improvement (p < 0.05) in the PPD, CAL and BOP+ comparing them with BL and one month after the periodontal treatment and a significant reduction (p < 0.05) for Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola in both groups. In addition, the improvement of clinical parameters was observed with subgingival use of EEP and also statistically significant differences between groups were observed (p < 0.05) such as reductions of BOP+ % and reduced counts of T. forsythensis and P. gingivalis, considered as the “key pathogens” for the periodontal diseases. Our results suggest prophylactic and therapeutic potential for EEP against periodontal diseases, improving clinical parameters, reducing gingival bleeding and decreasing bacterial counts of T. forsythensis and P. gingivalis. The subgingival use of EEP represents a promising modality as an adjuvant in periodontal therapy to avoid microbial resistance and other adverse effects. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cb7ae2a66a80c2f8e7bebac3b62be9 https://hdl.handle.net/10668/4209 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....16cb7ae2a66a80c2f8e7bebac3b62be9 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |