Unusual Case of Resistance to Amphotericin B in Visceral Leishmaniasis in a Region in India Where Leishmaniasis Is Not Endemic
| العنوان: | Unusual Case of Resistance to Amphotericin B in Visceral Leishmaniasis in a Region in India Where Leishmaniasis Is Not Endemic |
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| المؤلفون: | Pankaj Srivastava, Vijay Kumar Prajapati, Madhukar Rai, Shyam Sundar |
| المصدر: | Journal of Clinical Microbiology. 49:3088-3091 |
| بيانات النشر: | American Society for Microbiology, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Microbiology (medical), medicine.medical_specialty, Molecular Sequence Data, Antiprotozoal Agents, Drug Resistance, Mutation, Missense, Leishmania donovani, India, Single-nucleotide polymorphism, Case Reports, Drug resistance, Biology, Polymorphism, Single Nucleotide, Cysteine Proteases, Amphotericin B, Molecular genetics, medicine, Humans, Peptide sequence, Aged, Gene Expression Profiling, Leishmaniasis, Sequence Analysis, DNA, medicine.disease, biology.organism_classification, Virology, Molecular biology, Molecular Weight, Visceral leishmaniasis, Leishmaniasis, Visceral, medicine.drug |
| الوصف: | The case of a patient with visceral leishmaniasis showing inadequate response to amphotericin B from a region where leishmaniasis is not endemic is reported, with the Leishmania donovani isolate showing increased tolerance to amphotericin B in vivo . Four single nucleotide polymorphisms (SNPs) detected in the cysteine proteinase B gene resulted in changes to the deduced amino acid sequence: valine→alanine and arginine→leucine. Overexpression and underexpression of proteins were observed in the 65- to 80-kDa range and at 20 kDa, respectively. |
| تدمد: | 1098-660X 0095-1137 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e0ca1435fc9b5dff88b11cf3f0d177 https://doi.org/10.1128/jcm.00173-11 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....16e0ca1435fc9b5dff88b11cf3f0d177 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1098660X 00951137 |
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