Hydrogel spacer shrinkage during external-beam radiation therapy following low-dose-rate brachytherapy for high-risk prostate cancer: a case series
| العنوان: | Hydrogel spacer shrinkage during external-beam radiation therapy following low-dose-rate brachytherapy for high-risk prostate cancer: a case series |
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| المؤلفون: | Shuichi Ozawa, Koichi Wadasaki, Hideharu Miura, Hideo Kawabata, Mitsuru Kajiwara, Masahiro Kenjo, Katsumaro Kubo, Yasushi Nagata, Minoru Nakao, Yoshiko Doi |
| المصدر: | Journal of Medical Case Reports Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_treatment, Brachytherapy, External-beam radiation therapy, Case Report, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, medicine, Humans, Irradiation, Radiation treatment planning, medicine.diagnostic_test, business.industry, Rectum, Prostatic Neoplasms, Hydrogels, Radiotherapy Dosage, Magnetic resonance imaging, General Medicine, Seed Implantation, medicine.disease, Low-Dose Rate Brachytherapy, Hydrogel spacer, Radiation therapy, 030220 oncology & carcinogenesis, Medicine, Nuclear medicine, business |
| الوصف: | Background Few studies have assessed hydrogel spacer shrinkage during external-beam radiation therapy following brachytherapy for localized high-risk prostate cancer. This case presentation evaluated the changes in hydrogel spacer appearance by magnetic resonance imaging during external-beam radiation therapy after brachytherapy for prostate cancer and analyzed the effect of this shrinkage on the dose distribution in four cases. Case presentation In all cases, we implanted 125I sources using a modified peripheral loading pattern for seed placement. The prescribed dose for each implant was 110 Gy. After delivering the sources, a hydrogel spacer was injected. All cases underwent external-beam radiation therapy approximately 1–2 months after brachytherapy. The prescribed dose of external-beam radiation therapy was 45 Gy in 1.8-Gy fractions. Magnetic resonance imaging was performed for evaluation on the day following seed implantation (baseline), at external-beam radiation therapy planning, and during external-beam radiation therapy. The median hydrogel spacer volume was 16.2 (range 10.9–17.7) cc at baseline, 14.4 (range, 9.4–16.1) cc at external-beam radiation therapy planning, and 7.1 (range, 2.0–11.4) cc during external-beam radiation therapy. The hydrogel spacer volume during external-beam radiation therapy was significantly lower than that at external-beam radiation therapy planning. The rectum V60–80 (rectal volume receiving at least 60–80% of the prescribed dose of external-beam radiation therapy) during external-beam radiation therapy was significantly higher than that at external-beam radiation therapy planning. Conclusions The potential reduction in hydrogel spacer size during external-beam radiation therapy following brachytherapy can lead to unexpected irradiation to the rectum. This case presentation would be helpful for similar cases. |
| تدمد: | 1752-1947 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1701360a4c0c87112aaa29902a0a69ad https://doi.org/10.1186/s13256-021-02864-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1701360a4c0c87112aaa29902a0a69ad |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17521947 |
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