Role of distal cerebral vasculature in vessel constriction after aneurysm treatment with flow diverter stents
| العنوان: | Role of distal cerebral vasculature in vessel constriction after aneurysm treatment with flow diverter stents |
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| المؤلفون: | Christophe Cognard, Alberto Marzo, Frédéric Patat, Fernando Silva de Moura, Anne-Christine Januel, Ignacio Larrabide, René Chapot, Ana Paula Narata, Ayache Bouakaz, Stéphane Velasco |
| المصدر: | Journal of NeuroInterventional Surgery. 12:818-826 |
| بيانات النشر: | BMJ, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Hemodynamics, Constriction, Pathologic, 030218 nuclear medicine & medical imaging, Constriction, 03 medical and health sciences, Cerebral circulation, 0302 clinical medicine, Aneurysm, Internal medicine, medicine, Humans, Flow diverter, business.industry, Ultrasound, Intracranial Aneurysm, General Medicine, Blood flow, medicine.disease, Radiography, Treatment Outcome, medicine.anatomical_structure, Hydrodynamics, Cardiology, Vascular resistance, Stents, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | BackgroundTreatment of intracranial aneurysms with flow diverter stent (FDS) procedures can lead to caliber changes of jailed vessels. The reason some branches remain unchanged and others are affected by narrowing remains unknown.ObjectiveTo investigate the influence of resistance to flow from distal vasculature on stent-induced hemodynamic modifications affecting bifurcating vessels.Materials and methodsRadiological images and demographic data were acquired for 142 aneurysms treated with a FDS. Vascular resistance was estimated from patient-specific anatomic data. Correlation analysis was used to identify correspondence between anatomic data and clinical outcome. Computational Fluid Dynamics was performed on a typical patient-specific model to evaluate the influence of FDS on flow. Relevant hemodynamic variables along the bifurcating vessels were quantitatively analyzed and validated with in vitro data obtained using power Doppler ultrasound.ResultsStatistical analysis showed a correlation between clinical outcome and FDS resistance to flow considering overall jailed vessel vascular resistance (r=0.5, PConclusionsJailed vessels are affected by narrowing when resistance to flow from the FDS constitutes a larger proportion of the overall vessel resistance to flow. This knowledge may contribute to better understanding of intracranial hemodynamics after a FDS procedure and reinforce indications for flow diversion in the treatment of intracranial aneurysms. |
| وصف الملف: | application/pdf |
| تدمد: | 1759-8486 1759-8478 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172c71ff366208c12f08e5a1d09ec270 https://doi.org/10.1136/neurintsurg-2019-015447 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....172c71ff366208c12f08e5a1d09ec270 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17598486 17598478 |
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