T cell circuits that sense antigen density with an ultrasensitive threshold
| العنوان: | T cell circuits that sense antigen density with an ultrasensitive threshold |
|---|---|
| المؤلفون: | Anna Mari Mäkelä, Wei Yu, Olivia A. Creasey, Rogelio A. Hernandez-Lopez, Wendell A. Lim, Kalle Saksela, Arsenia De Guzman, Yurie Tonai, Maria del Pilar Lopez Pazmino, Zev J. Gartner, Katelyn A. Cabral |
| المساهمون: | Department of Virology, University of Helsinki, HUSLAB, Infection Biology Research Program, Kalle Saksela / Principal Investigator |
| المصدر: | Science (New York, N.Y.), vol 371, iss 6534 Signal Transduction and Targeted Therapy |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cytotoxic, Receptor, ErbB-2, medicine.medical_treatment, T-Lymphocytes, Adoptive, Translational immunology, Immunotherapy, Adoptive, Mice, 0302 clinical medicine, ErbB-2, Receptors, Cytotoxic T cell, 2.1 Biological and endogenous factors, Epidermal growth factor receptor, Aetiology, Cell Engineering, Cancer, 0303 health sciences, Receptors, Chimeric Antigen, Multidisciplinary, Tumor, Receptors, Notch, biology, Chemistry, Receptors, Artificial, Research Highlight, Cell biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Artificial, Tumour immunology, Immunotherapy, Development of treatments and therapeutic interventions, Receptor, Biotechnology, Notch, General Science & Technology, T cell, Cell Line, 03 medical and health sciences, Antigen, Antigens, Neoplasm, Cell Line, Tumor, Spheroids, Cellular, Breast Cancer, medicine, Animals, Humans, Antigens, 030304 developmental biology, 5.2 Cellular and gene therapies, Chimeric Antigen, Xenograft Model Antitumor Assays, Chimeric antigen receptor, Preclinical research, Cell culture, Cancer cell, biology.protein, Neoplasm, Cellular, 3111 Biomedicine, Spheroids, K562 Cells, T-Lymphocytes, Cytotoxic |
| الوصف: | Designing smarter anticancer T cells Biological signaling systems can exhibit a large, nonlinear—or “ultrasensitive”—response, which would be useful to engineer into therapeutic T cells to allow for better discrimination between cancer cells and normal tissues. Hernandez-Lopez et al. modified human T cells using a two-step mechanism that allowed them to kill cells expressing large amounts of cancer marker protein but not cells expressing a small amount of the same protein. A first synthetic receptor recognized the antigen with low affinity. That receptor signaled to increase expression of a chimeric antigen receptor (CAR) with high affinity for the same antigen. The circuit proved effective in cell culture and mouse cancer models, offering hope of extending the CAR T cell strategy against solid tumors. Science , this issue p. 1166 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17502ef02f02cbeb725abce025f42071 http://hdl.handle.net/10138/330717 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....17502ef02f02cbeb725abce025f42071 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |