T cell-specific deficiency in BBSome component BBS1 interferes with selective immune responses
| العنوان: | T cell-specific deficiency in BBSome component BBS1 interferes with selective immune responses |
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| المؤلفون: | Madeliene Stump, Deng Fu Guo, Kamal Rahmouni |
| المصدر: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R161-R170 |
| بيانات النشر: | American Physiological Society, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology, Physiology (medical) |
| الوصف: | Bsardet Biedl syndrome (BBS) is a genetic condition associated with various clinical features including cutaneous disorders and certain autoimmune and inflammatory diseases pointing to a potential role of BBS proteins in the regulation of immune function. BBS1 protein, which is a key component of the BBSome, a protein complex involved in the regulation of cilia function and other cellular processes, has been implicated in the immune synapse assembly by promoting the centrosome polarization to the antigen-presenting cells. Here, we assessed the effect of disrupting the BBSome, through Bbs1 gene deletion, in T cells. Interestingly, mice lacking the Bbs1 gene specifically in T cells ( T-BBS1−/−) displayed normal body weight, adiposity, and glucose handling, but have smaller spleens. However, T-BBS1−/− mice had no change in the proportion and absolute number of B cells and T cells in the spleen and lymph nodes. There was also no alteration in the CD4/CD8 lineage commitment or survival in the thymus of T-BBS1−/− mice. On the other hand, T-BBS1−/− mice treated with Imiquimod dermally exhibited a significantly higher percentage of CD3-positive splenocytes that was due to CD4 but not CD8 T cell predominance. Notably, we found that T-BBS1−/− mice had significantly decreased wound closure, an effect that was more pronounced in males indicating that the BBSome plays an important role in T cell-mediated skin repair. Together, these findings implicate the BBSome in the regulation of selective functions of T cells. |
| تدمد: | 1522-1490 0363-6119 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175516630e504821ada9a97e195826c7 https://doi.org/10.1152/ajpregu.00243.2022 |
| رقم الأكسشن: | edsair.doi.dedup.....175516630e504821ada9a97e195826c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221490 03636119 |
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