Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity
| العنوان: | Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity |
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| المؤلفون: | Nicki N. Jariwala, Samrachana Adhikari, Christopher J. Trentacosta, Claudia Espinoza-Heredia, Alan Chen, Ava C. Palopoli, Denise M. Werchan, Natalie H. Brito, Moriah E. Thomason |
| المصدر: | Developmental Cognitive Neuroscience, Vol 51, Iss, Pp 101000-(2021) Developmental Cognitive Neuroscience |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Neurophysiology and neuropsychology, THC, Cognitive Neuroscience, Physiology, Hippocampal formation, Gyrus Cinguli, Hippocampus, Fetal, Resting-state, Pregnancy, medicine, Humans, Prenatal, Dronabinol, Child, Original Research, Cannabis, Fetus, biology, Resting state fMRI, QP351-495, Infant, Brain, Human brain, biology.organism_classification, Magnetic Resonance Imaging, medicine.anatomical_structure, Posterior cingulate, Child, Preschool, Connectome, Female, Psychology, Insula |
| الوصف: | Increasing evidence supports a link between maternal prenatal cannabis use and altered neural and physiological development of the child. However, whether cannabis use relates to altered human brain development prior to birth, and specifically, whether maternal prenatal cannabis use relates to connectivity of fetal functional brain systems, remains an open question. The major objective of this study was to identify whether maternal prenatal cannabis exposure (PCE) is associated with variation in human brain hippocampal functional connectivity prior to birth. Prenatal drug toxicology and fetal fMRI data were available in a sample of 115 fetuses [43 % female; mean age 32.2 weeks (SD = 4.3)]. Voxelwise hippocampal connectivity analysis in a subset of age and sex-matched fetuses revealed that PCE was associated with alterations in fetal dorsolateral, medial and superior frontal, insula, anterior temporal, and posterior cingulate connectivity. Classification of group differences by age 5 outcomes suggest that compared to the non-PCE group, the PCE group is more likely to have increased connectivity to regions associated with less favorable outcomes and to have decreased connectivity to regions associated with more favorable outcomes. This is preliminary evidence that altered fetal neural connectome may contribute to neurobehavioral vulnerability observed in children exposed to cannabis in utero. |
| اللغة: | English |
| تدمد: | 1878-9293 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175b6d9b6b646c25d3040c06b219ccd9 http://www.sciencedirect.com/science/article/pii/S1878929321000906 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....175b6d9b6b646c25d3040c06b219ccd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18789293 |
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