| الوصف: |
The present study was done to explore the pharmacokinetics of ciprofloxacinthat was altered by co-administration of either diclofenac oribuprofen. The study was conducted on twelve Myanmar healthy volunteersand divided into three phases with a wash out period of one week inbetween phases. In phase, ciprofloxacin 500 mg was given to all volunteers,ciprofloxacin 500 mg with diclofenac 50 mg was given to same volunteersin phase 2 and ciprofloxacin 500 mg with ibuprofen 400 mg was given inphase 3. Blood samples were collected at 0, 0.5, 1, 2, 3, 4, 6 and 8 hours\after drugs administration and ciprofloxacin concentrations in plasmasamples were analyzed by HPLC with UV detection. It was found thatmean clearance was reduced from 0.38±0.11 Lhr-1kg-1 in ciprofloxacinalone to 0.30±0.07 Lhr-1kg-1 and 0.28±0.09 Lhr-1kg-1 in ciprofloxacin withdiclofenac and ciprofloxacin with ibuprofen (p=0.019). Similarly, the meanelimination rate constants (Kel) was significantly reduced from 0.24±0.03 hr-1inciprofloxacin alone to 0.18±0.024 hr-1 in ciprofloxacin with diclofenacand 0.12±0.03 hr-1 in ciprofloxacin with ibuprofen co-administration(p=0.000). Increase in AUC of ciprofloxacin was founded that AUC ofciprofloxacin alone was 13.51±1.91 μgml-1.hr, ciprofloxacin with diclofenacwas 17.36±2.67 μgml-1.hr and with ibuprofen was 18.43±4.08 μgml-1.hr,respectively (p=0.001). |
