Evidence for clonal selection of gamma/delta T cells in response to a human pathogen
| العنوان: | Evidence for clonal selection of gamma/delta T cells in response to a human pathogen |
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| المؤلفون: | K Uyemura, R J Deans, H Band, J Ohmen, G Panchamoorthy, C T Morita, T H Rea, R L Modlin |
| المصدر: | The Journal of experimental medicine, vol 174, iss 3 The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Delta, T cell, Molecular Sequence Data, Immunology, Receptors, Antigen, T-Cell, Biology, Gene Rearrangement, T-Lymphocyte, Polymerase Chain Reaction, Medical and Health Sciences, Immune system, Antigen, T-Lymphocyte Subsets, Receptors, medicine, Humans, Immunology and Allergy, Amino Acid Sequence, Lepromin, Skin, Skin Tests, Gene Rearrangement, gamma-delta, Delta cell, gamma-Chain T-Cell Antigen Receptor, Base Sequence, Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, T-cell receptor, Receptors, Antigen, T-Cell, gamma-delta, Articles, Gene rearrangement, T-Cell, Junctional diversity, Clone Cells, medicine.anatomical_structure, T-Lymphocyte |
| الوصف: | T cells bearing gamma/delta antigen receptors comprise a resident population of intraepithelial lymphocytes in organs such as skin, gut, and lungs, where they are strategically located to contribute to the initial defense against infection. An important unsolved question about antigen-driven gamma/delta T cell responses regards the breadth of their T cell receptor (TCR) repertoire, since many specific epithelial compartments in mice display limited diversity. We have examined the diversity of TCR delta gene expression among human gamma/delta T cells from skin lesions induced by intradermal challenge with Mycobacterium leprae. We show that the vast majority of gamma/delta cells from M. leprae lesions use either V delta 1-J delta 1 or V delta 2-J delta 1 gene rearrangements and, within a given region of the lesion, display limited junctional diversity. This contrasts markedly with the extensive diversity of gamma/delta T cells from peripheral blood of these same individuals, as well as skin from normal donors. These results indicate that the gamma/delta response to M. leprae involves the selection of a limited number of clones from among a diverse repertoire, probably in response to specific mycobacterial and/or host antigens. |
| وصف الملف: | application/pdf |
| تدمد: | 1540-9538 0022-1007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1838d2fadb4d4d4edfbe5196421efca0 https://doi.org/10.1084/jem.174.3.683 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1838d2fadb4d4d4edfbe5196421efca0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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