Stunting in pre-school and school-age children in the Peruvian highlands and its association with Fasciola infection and demographic factors
| العنوان: | Stunting in pre-school and school-age children in the Peruvian highlands and its association with Fasciola infection and demographic factors |
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| المؤلفون: | Maria Luisa Morales, A. Clinton White, Martha Lopez, Eulogia Arque, Camille M. Webb, Benicia Baca-Turpo, Miguel M. Cabada |
| المصدر: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009519 (2021) |
| بيانات النشر: | Public Library of Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, RC955-962, Flatworms, Families, Feces, 0302 clinical medicine, Medical Conditions, Arctic medicine. Tropical medicine, Peru, Socioeconomic aspects of health, Medicine and Health Sciences, Public and Occupational Health, 030212 general & internal medicine, Child, Children, Growth Disorders, Fasciola, biology, Altitude, Eukaryota, Anemia, Parasitic diseases, Socioeconomic Aspects of Health, Infectious Diseases, Helminth Infections, Child, Preschool, Female, medicine.symptom, Public aspects of medicine, RA1-1270, Research Article, Neglected Tropical Diseases, Fascioliasis, Helminth infections, Adolescent, 030231 tropical medicine, Antibodies, Helminth, Standard score, Asymptomatic, Trematodes, Child Nutrition Disorders, 03 medical and health sciences, Helminths, parasitic diseases, medicine, Parasitic Diseases, Animals, Humans, Medical history, Socioeconomic status, Nutrition, business.industry, Malnutrition, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, biology.organism_classification, medicine.disease, Tropical Diseases, Invertebrates, Health Care, Cross-Sectional Studies, Socioeconomic Factors, Age Groups, People and Places, Population Groupings, business, Zoology, Demography |
| الوصف: | Fascioliasis is a zoonotic trematode infection that is endemic in the highlands of Peru. Chronic fascioliasis can be asymptomatic and remain undiagnosed for years. Chronic malnutrition in children, as manifested by stunting, leads to delayed cognitive development and lost productivity. We hypothesized that fascioliasis is among the factors associated with stunting in children from endemic areas. We conducted a cross-sectional study among children attending pre-school and school in 26 communities in the Anta province in the Cusco region of Peru. We conducted interviews to collect information on demographic, socioeconomic, and medical history. Blood was collected and tested for complete cell count and FAS2 ELISA for Fasciola antibodies. Three stool samples per participant were tested for parasites by Kato-Katz and Lumbreras rapid sedimentation methods. Chronic fascioliasis was determined by the presence of ova in stool. Children’s height, weight, and age were recorded and used to calculate height for age Z scores (HAZ). Three thousand children participated in the study. Nine percent (264) of children had at least one positive test for Fasciola infection, 6% (164) had chronic fascioliasis, and 3% (102) had only positive antibody tests. The median HAZ was -1.41 (IQR: -2.03 to -0.81) and was similar in males and females. Twenty six percent (776) of children had stunting with HAZ < -2. Children with chronic fascioliasis had a lower median HAZ than children without Fasciola (-1.54 vs. -1.4, p = 0.014). History of treatment for malnutrition, history of treatment for anemia, having other helminths in stool, lower socioeconomic score, living at a higher elevation, and fewer years of schooling of both parents were associated with a lower HAZ score. In a multiple regression analysis, older age and a lower socioeconomic score were associated with a lower HAZ score. While fascioliasis and other helminths were associated with lower HAZ, they were not independent of the socioeconomic score. Author summary Fasciola infection is endemic in the highlands of Peru. Children in the highlands are particularly affected. The effect of chronic fascioliasis on children’s long-term health and development, particularly the impact on nutrition, is not well defined. In this large epidemiologic study, we evaluated the association of chronic Fasciola infection with chronic malnutrition. Children with chronic Fasciola, defined as finding Fasciola eggs in stool, had a lower height for age Z score than those without Fasciola. A lower poverty score, fewer years of education of parents, and higher house elevation were also associated with stunted growth. |
| اللغة: | English |
| تدمد: | 1935-2735 1935-2727 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18474adcc3f43a7561aa0397c7d7f745 http://europepmc.org/articles/PMC8248620 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....18474adcc3f43a7561aa0397c7d7f745 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19352735 19352727 |
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