Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion
| العنوان: | Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion |
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| المؤلفون: | Bernard T. Kenney, Robert M. Ferris, Nariman B. Mehta, F. E. Soroko, Elizabeth B. Hollingsworth, David Lee Musso |
| المصدر: | Chirality. 5:495-500 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Male, Biogenic Amines, Serotonin, Dopamine, Sedation, Tetrabenazine, Hypothalamus, Mice, Inbred Strains, Pharmacology, Chemical synthesis, Catalysis, Analytical Chemistry, Mice, Norepinephrine, Structure-Activity Relationship, In vivo, Biogenic amine, Drug Discovery, medicine, Animals, Bupropion, Spectroscopy, chemistry.chemical_classification, Chemistry, fungi, Organic Chemistry, Stereoisomerism, Corpus Striatum, Antidepressant, Indicators and Reagents, medicine.symptom, Enantiomer, Reuptake inhibitor, Synaptosomes, medicine.drug |
| الوصف: | The synthesis of the enantiomers of bupropion, (rac)-2-tert-butylamino-3′-chloropropiophenone 1 (Wellbutrin®) is described. The enantiomers were compared with the racemate in both the tetrabenazine-induced sedation model and the inhibition of uptake of biogenic amine assay. No significant differences were found in their potencies to reverse tetrabenazine-induced sedation in mice or in their IC50 values as inhibitors of biogenic amine uptake into nerve endings obtained from mouse brain. © 1993 Wiley-Liss, Inc. |
| تدمد: | 1520-636X 0899-0042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18518f98e7a8951a6d8c0c468f0ef3b7 https://doi.org/10.1002/chir.530050704 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....18518f98e7a8951a6d8c0c468f0ef3b7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1520636X 08990042 |
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