γδ T/Interleukin-17A Contributes to the Effect of Maresin Conjugates in Tissue Regeneration 1 on Lipopolysaccharide-Induced Cardiac Injury
| العنوان: | γδ T/Interleukin-17A Contributes to the Effect of Maresin Conjugates in Tissue Regeneration 1 on Lipopolysaccharide-Induced Cardiac Injury |
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| المؤلفون: | Yi Yang, Xin-Yu Li, Lin-Chao Li, Ji Xiao, Yin-Meng Zhu, Yang Tian, Yong-Mao Sheng, Yan Chen, Jian-Guang Wang, Sheng-Wei Jin |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cardiac function curve, cardiac injury, Lipopolysaccharide, Immunology, Inflammation, Stimulation, 030204 cardiovascular system & hematology, Pharmacology, interleukin-17A, γδ T cells, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Immunology and Allergy, Maresin, Original Research, Chemistry, lipopolysaccharide, neutrophil, Chemotaxis, RC581-607, 030104 developmental biology, Interleukin 17, Immunologic diseases. Allergy, medicine.symptom, Signal transduction |
| الوصف: | The mechanisms underlying sepsis-induced cardiomyopathy (SIC) remain poorly understood, and there are no specific therapeutics for SIC. We investigated the effects of maresin conjugates in tissue regeneration 1 (MCTR1) on SIC and explored its potential mechanisms. The experiments were conducted using an endotoxemia model induced by lipopolysaccharide (LPS). Mice were given MCTR1 intravenously 6 h after LPS stimulation. Echocardiography was performed to assess cardiac function 12 h after LPS administration. Treatment with MCTR1 significantly enhanced cardiac function and reduced LPS-induced increase of mRNA expression levels of inflammation cytokines. Transcriptomic analysis indicated that MCTR1 inhibited neutrophil chemotaxis via the IL-17 signaling pathway. We confirmed that MCTR1 reduced the expressions of neutrophil chemoattractants and neutrophil infiltration in the LPS-stimulated hearts. MCTR1 also resulted in a considerable reduction in IL-17A production mainly derived from γδ T cells. Moreover, our results provided the first evidence that neutralizing IL-17A or depletion of γδ T cells markedly decreased neutrophil recruitment and enhanced cardiac function in LPS-induced cardiac injury. These results suggest that MCTR1 alleviates neutrophil infiltration thereby improves cardiac function in LPS-induced cardiac injury via the IL-17 signaling pathway. Thus, MCTR1 represented a novel therapeutic strategy for patients with SIC. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18994091497516893d7e7e13de3173fa http://europepmc.org/articles/PMC8107383 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....18994091497516893d7e7e13de3173fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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