Chemotherapy with cisplatin and paclitaxel in patients with locally advanced, recurrent or metastatic oesophageal cancer
| العنوان: | Chemotherapy with cisplatin and paclitaxel in patients with locally advanced, recurrent or metastatic oesophageal cancer |
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| المؤلفون: | U. Graeven, A Welt, W. Schmiegel, S. Petrasch, A Reinacher, M König |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, Paclitaxel, medicine.medical_treatment, Adenocarcinoma, Neutropenia, Metastasis, chemistry.chemical_compound, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Carcinoma, Humans, Neoplasm Metastasis, Aged, Cisplatin, Chemotherapy, business.industry, Cancer, Middle Aged, medicine.disease, chemistry, Carcinoma, Squamous Cell, Female, Neoplasm Recurrence, Local, business, Research Article, medicine.drug |
| الوصف: | Single-agent therapy with paclitaxel is effective against both squamous cell carcinoma and adenocarcinoma of the oesophagus. However, only limited data are available on the combination of paclitaxel with other cytotoxic drugs in this entity. Patients with unresectable stage III, recurrent or metastatic tumours were treated in a multicentre setting with paclitaxel 90 mg m(-2) given over 3 h intravenously, followed by cisplatin 50 mg m(-2). The courses were repeated every 14 days. Twenty patients with squamous cell carcinoma or adenocarcinoma of the oesophagus were evaluable for response. The overall remission rate was 40% (8/20), including 15% (3/20) clinically complete responses. Clinical benefit response, defined as relief of dysphagia and/or significant gain in weight, was achieved in 70% of the patients. Neutropenia of CTC grade 3 occurred only in 10% of the patients; no grade 4 neutropenia and no severe thrombocytopenia was encountered. CTC grade 4 neurotoxicity was seen in 5% of patients. Cisplatin/paclitaxel administered every 14 days, was effective in patients with poor prognosis oesophageal cancer and toxicity was acceptable. |
| تدمد: | 1532-1827 0007-0920 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198b9ab0794379f8fb9b62b22d12425c https://doi.org/10.1038/bjc.1998.524 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....198b9ab0794379f8fb9b62b22d12425c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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