Within- and between-subject biological variation data for serum zinc, copper and selenium obtained from 68 apparently healthy Turkish subjects
| العنوان: | Within- and between-subject biological variation data for serum zinc, copper and selenium obtained from 68 apparently healthy Turkish subjects |
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| المؤلفون: | Mustafa Serteser, Anna Carobene, Emine Kızılkaya, Aasne K. Aarsand, Pilar Fernandez-Calle, Niels Jonker, Fatma Hande Karpuzoglu, Ibrahim Unsal, Cihan Coskun, Esra Ugur, Fehime Benli Aksungar, Damla Fidan, Jorge Díaz-Garzón, Abdurrahman Coskun, Sverre Sandberg |
| المساهمون: | Acibadem University Dspace |
| المصدر: | Clinical Chemistry and Laboratory Medicine |
| بيانات النشر: | Walter de Gruyter GmbH, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Clinical Biochemistry, chemistry.chemical_element, biological variation (BV), copper (Cu), Zinc, Population based, selenium (Se), Selenium, Animal science, Biological variation, Humans, zinc (Zn), Serum zinc, trace elements (TrEL), Biochemistry (medical), Healthy subjects, General Medicine, Serum samples, Copper, Healthy Volunteers, Trace Elements, Biological Variation, Population, chemistry, Female |
| الوصف: | Objectives Trace elements (TrEL) are nutritionally essential components in maintaining health and preventing diseases. There is a lack of reliable biological variation (BV) data for TrELs, required for the diagnosis and monitoring of TrEL disturbances. In this study, we aimed to provide updated within- and between-subject BV estimates for zinc (Zn), copper (Cu) and selenium (Se). Methods Weekly serum samples were drawn from 68 healthy subjects (36 females and 32 males) for 10 weeks and stored at −80 °C prior to analysis. Serum Zn, Cu and Se levels were measured using inductively-coupled plasma mass spectrometry (ICP-MS). Outlier and variance homogeneity analyses were performed followed by CV-ANOVA (Røraas method) to determine BV and analytical variation estimates with 95% CI and the associated reference change values (RCV) for all subjects, males and females. Results Significant differences in mean concentrations between males and females were observed, with absolute and relative (%) differences for Zn at 0.5 μmol/L (3.5%), Cu 2.0 μmol/L (14.1%) and Se 0.06 μmol/L (6.0%). The within-subject BV (CVI [95% CI]) estimates were 8.8% (8.2–9.3), 7.8% (7.3–8.3) and 7.7% (7.2–8.2) for Zn, Cu and Se, respectively. Within-subject biological variation (CVI) estimates derived for male and female subgroups were similar for all three TrELs. Marked individuality was observed for Cu and Se. Conclusions The data of this study provides updated BV estimates for serum Zn, Cu and Se derived from a stringent protocol and state of the art methodologies. Furthermore, Cu and Se display marked individuality, highlighting that population based reference limits should not be used in the monitoring of patients. |
| وصف الملف: | application/pdf |
| تدمد: | 1437-4331 1434-6621 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198f814809f912e9084b8b3814f4ed6f https://doi.org/10.1515/cclm-2021-0886 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....198f814809f912e9084b8b3814f4ed6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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