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Mind-body exercise improves cognitive function and modulates the function and structure of the hippocampus and anterior cingulate cortex in patients with mild cognitive impairment

التفاصيل البيبلوغرافية
العنوان: Mind-body exercise improves cognitive function and modulates the function and structure of the hippocampus and anterior cingulate cortex in patients with mild cognitive impairment
المؤلفون: Lidian Chen, Xiangli Chen, Rui Xia, Guohua Zheng, Maomao Huang, Jian Kong, Georgia Wilson, Joel Park, Courtney Lang, Jiao Liu, Moyi Li, Binlong Zhang, Guanli Xie, Shuzhen Li, Jing Tao
المصدر: NeuroImage: Clinical, Vol 23, Iss, Pp-(2019)
بيانات النشر: Elsevier, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, medicine.medical_specialty, Cognitive Neuroscience, Neurological disorder, lcsh:Computer applications to medicine. Medical informatics, Gyrus Cinguli, Hippocampus, lcsh:RC346-429, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Cognition, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Cognitive Dysfunction, Cognitive impairment, Exercise, lcsh:Neurology. Diseases of the nervous system, Anterior cingulate cortex, Aged, medicine.diagnostic_test, Resting state fMRI, business.industry, Mind-Body Therapies, 05 social sciences, Montreal Cognitive Assessment, Magnetic resonance imaging, Regular Article, Voxel-based morphometry, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Exercise Therapy, medicine.anatomical_structure, Neurology, lcsh:R858-859.7, Female, Neurology (clinical), business, human activities, 030217 neurology & neurosurgery
الوصف: Mild cognitive impairment (MCI) is a common neurological disorder. This study aims to investigate the modulation effect of Baduanjin (a popular mind-body exercise) on MCI. 69 patients were randomized to Baduanjin, brisk walking, or an education control group for 24 weeks. The Montreal Cognitive Assessment (MoCA) and Magnetic Resonance Imaging scans were applied at baseline and at the end of the experiment. Compared to the brisk walking and control groups, the Baduanjin group experienced significantly increased MoCA scores. Amplitude of low-frequency fluctuations (ALFF) analysis showed significantly decreased ALFF values in the right hippocampus (classic low-freqency band, 0.01‐0.08 Hz) in the Baduanjin group compared to the brisk walking group and increased ALFF values in the bilateral anterior cingulate cortex (ACC, slow-5 band, 0.01-0.027 Hz) in the Baduanjin group compared to the control group. Further, ALFF value changes in the right hippocampus and bilateral ACC were significantly associated with corresponding MoCA score changes across all groups. We also found increased gray matter volume in the Baduanjin group in the right hippocampus compared to the brisk walking group and in the bilateral ACC compared to the control group. In addition, there was an increased resting state functional connectivity between the hippocampus and right angular gyrus in the Baduanjin group compared to the control group. Our results demonstrate the potential of Baduanjin for the treatment of MCI. Keywords: Mind-body intervention, Baduanjin, Resting state functional connectivity, Voxel-based morphometry, Mild cognitive impairment, Hippocampus, Anterior cingulate cortex
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a45010bbf6dc64130b0bf3ba3c5b07
https://europepmc.org/articles/PMC6535682/
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....19a45010bbf6dc64130b0bf3ba3c5b07
قاعدة البيانات: OpenAIRE
الوصف
الوصف غير متاح.