Red blood cell distribution width and peritoneal dialysis-associated peritonitis prognosis
| العنوان: | Red blood cell distribution width and peritoneal dialysis-associated peritonitis prognosis |
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| المؤلفون: | Lijie He, Jin-Ping Hu, Peng He, Shiren Sun, Huan Li, Chen Huang, Xiu-Juan Tian |
| المصدر: | Renal Failure, Vol 42, Iss 1, Pp 613-621 (2020) Renal Failure article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Erythrocyte Indices, Male, Erythrocytes, medicine.medical_treatment, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Logistic regression, lcsh:RC870-923, Gastroenterology, 0302 clinical medicine, Peritoneal Dialysis, Continuous Ambulatory, Recurrence, Treatment Failure, Area under the curve, General Medicine, Middle Aged, Prognosis, peritoneal dialysis, Nephrology, Female, Research Article, Adult, China, medicine.medical_specialty, Peritonitis, Peritoneal dialysis, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Renal Insufficiency, Chronic, Aged, Retrospective Studies, business.industry, Continuous ambulatory peritoneal dialysis, Red blood cell distribution width, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, Confidence interval, Logistic Models, ROC Curve, Clinical Study, red blood cell distribution width, business, peritoneal dialysis-associated peritonitis, chronic kidney disease, Kidney disease |
| الوصف: | Objective Red blood cell distribution width (RDW) is a parameter of the heterogeneity of circulating erythrocyte size. Recent researches have pointed out a link among RDW, chronic kidney disease, and inflammation. We sought to investigate the prognostic value of baseline RDW in patients with peritoneal dialysis-associated peritonitis (PDAP). Methods Our study included 337 peritonitis episodes experienced by 202 patients who were undergoing continuous ambulatory peritoneal dialysis (CAPD) at a single center from 2013 to 2018. Episodes were categorized according to the tertiles of baseline RDW levels (T1, 14.3%). Routine logistic regression and generalized estimating equation (GEE) were used to estimate the association between RDW and treatment failure, which was defined as relapse/recurrent episodes, catheter removal, or death during therapy. Results After adjusting for other potential predictors, RDW exhibited an incremental relationship with the risk of treatment failure. The baseline RDW of T3 indicated a 43% and 52% increased venture of treatment failure in logistic and GEE analyses, respectively, compared with T1. As a continuous variable, the fitting curve based on restricted cubic spiline showed that the relationship was nonlinearly but positively correlated. The multivariate model A (combined RDW with baseline age, albumin, serum ferritin, and duration on CAPD) showed an area under the curve of 0.671 (95% confidence interval, 0.5920.749) for the prediction of treatment failure. Conclusions A Higher baseline level of RDW was significantly associated with a greater rate of treatment failure among PDAP episodes independent of other potential predictors. |
| اللغة: | English |
| تدمد: | 1525-6049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19aacc3400e7fc87d9bac108ad962176 https://doaj.org/article/a4535ab1ad3f41fba6d6f6877616e8de |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....19aacc3400e7fc87d9bac108ad962176 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15256049 |
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