Tumor motion and deformation during external radiotherapy of bladder cancer
| العنوان: | Tumor motion and deformation during external radiotherapy of bladder cancer |
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| المؤلفون: | Peter Remeijer, Heidi Lotz, Maarten C.C.M. Hulshof, Joos V. Lebesque, Floris J. Pos, Marcel van Herk, Joop C. Duppen |
| المساهمون: | Other departments, CCA -Cancer Center Amsterdam, Radiotherapy, Other Research, Biomedical Engineering and Physics, Faculteit Medische Wetenschappen/UMCG |
| المصدر: | International journal of radiation oncology, biology, physics, 64(5), 1551-1558. Elsevier Inc. International Journal of Radiation Oncology, Biology, Physics, 64(5), 1551-1558. ELSEVIER SCIENCE INC |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, Movement, Urinary Bladder, Computed tomography, External radiotherapy, Image Interpretation, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Tumor location, Tumor motion, Radiation, Bladder cancer, medicine.diagnostic_test, business.industry, medicine.disease, Bladder filling, Radiotherapy, Computer-Assisted, Gross tumor volume, Oncology, Urinary Bladder Neoplasms, Female, Radiology, Deformation (engineering), Nuclear medicine, business, Tomography, X-Ray Computed |
| الوصف: | Purpose: First, to quantify bladder-tumor motion in 3 dimensions during a 4-week to 5-week course of external radiotherapy. Second, to relate the motion to the tumor location on the bladder wall. Third, to extensively evaluate gross tumor volume (GTV) shape and volume changes during the course of the treatment.Methods and Materials: Multiple repeat computed tomography (CT) images were obtained for 21 bladder cancer patients. These scans were matched to the rigid bony anatomy. For each patient, the main direction and magnitude of the tumor movement was determined by use of principle-component analysis. To study GTV shape changes, all GTVs were registered to the GTV in the planning CT scan, and the residual shape errors were determined by measurement of edge variations perpendicular to the median surface.Results: Gross tumor volume translations were largest in cranial–caudal and anterior–posterior direction (SD, 0.1 to ∼0.9 cm). The translations were strongly correlated with the tumor location on the bladder wall. The average value of the local standard deviations of the GTV shape ranged from 0.1 to approximately 0.35 cm.Conclusions: Despite large differences in bladder filling, variations in GTV shape were small compared with variations in GTV position. Geometric uncertainties in the GTV position depended strongly on the tumor location on the bladder wall. |
| اللغة: | English |
| تدمد: | 0360-3016 0145-1464 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c072ec39de3b92da6058dea25bf6dd https://pure.amc.nl/en/publications/tumor-motion-and-deformation-during-external-radiotherapy-of-bladder-cancer(c72e69cd-6921-42e1-8835-c8c3721c9f21).html |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....19c072ec39de3b92da6058dea25bf6dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03603016 01451464 |
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