The Promoter SNP, but not the Alternative Splicing SNP, is Linked to Multiple Sclerosis Among Jordanian Patients
| العنوان: | The Promoter SNP, but not the Alternative Splicing SNP, is Linked to Multiple Sclerosis Among Jordanian Patients |
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| المؤلفون: | Bilal Samhouri, Ammar El-Omar, Leena Ibayyan, Mamoun Ahram, Rand Zaza, Mohammad El-khateeb, Said S. Dahbour |
| المصدر: | Journal of Molecular Neuroscience. 52:467-472 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Genotype, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Young Adult, Cellular and Molecular Neuroscience, Multiple Sclerosis, Relapsing-Remitting, medicine, Humans, SNP, Coding region, Promoter Regions, Genetic, Interleukin-7 receptor, Genetics, Jordan, Receptors, Interleukin-7, Multiple sclerosis, Alternative splicing, Promoter, General Medicine, Middle Aged, Multiple Sclerosis, Chronic Progressive, medicine.disease, Alternative Splicing, Female, Polymorphism, Restriction Fragment Length, HLA-DRB1 Chains |
| الوصف: | Multiple sclerosis is a chronic inflammatory autoimmune disease of the human central nervous system. A number of studies with compelling evidence have provided correlation between single nucleotide polymorphisms in interleukin-7 receptor alpha and multiple sclerosis (MS) in several populations. One such variation, rs6897932, is located within the coding region and results in the generation of a soluble receptor, whereas another one, rs11567685, is located in the promoter region and affects gene expression. In this study, we investigated the frequencies of these two SNPs and their association to MS in 200 healthy controls and 200 MS patients based on a simple PCR-RFLP strategy not reported previously. The frequencies of the high risk alleles for both SNPs were in a high range among healthy and MS subjects relative to previous studies. In addition, whereas no association was found between the alternative splicing SNP, rs6897932, and MS, a significant link was found between the promoter SNP, rs11567685, and MS. These results are in contrast to other studies and may have important implications as to the molecular contribution of IL-7Rα in multiple sclerosis. |
| تدمد: | 1559-1166 0895-8696 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19daf1b83c02392d9cea9db82ed55b16 https://doi.org/10.1007/s12031-013-0151-0 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....19daf1b83c02392d9cea9db82ed55b16 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15591166 08958696 |
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