The alpha‐melanocyte‐stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma
| العنوان: | The alpha‐melanocyte‐stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma |
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| المؤلفون: | Karoline I. Gaede, Christina Vock, Michael Wegmann, Heinz Fehrenbach, Alexandra Schröder, Lars Lunding, Christian Herzmann, Sina Webering |
| المصدر: | Clinical & Experimental Allergy. 49:1026-1039 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, Receptor expression, medicine.medical_treatment, Immunology, Inflammation, Pathogenesis, Mice, chemistry.chemical_compound, Th2 Cells, medicine, Animals, Humans, Immunology and Allergy, Lung, Asthma, Mice, Inbred BALB C, integumentary system, biology, medicine.diagnostic_test, business.industry, Middle Aged, respiratory system, medicine.disease, alpha-Melanocyte-stimulating hormone, respiratory tract diseases, Ovalbumin, Bronchoalveolar lavage, Cytokine, chemistry, alpha-MSH, biology.protein, Female, medicine.symptom, business, Bronchoalveolar Lavage Fluid, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Background Originally, the neuropeptide α-melanocyte-stimulating hormone (α-MSH) has been described as a mediator of skin pigmentation. However, recent studies have shown that α-MSH is able to modulate inflammation in various tissues including the lung. So far, it is still not clear whether α-MSH also plays a role in allergic bronchial asthma. Objective This study aimed at investigating the role and regulatory mechanisms of α-MSH in asthma pathogenesis. Methods α-MSH levels were measured in bronchoalveolar lavage (BAL) fluid of asthmatic and non-asthmatic individuals as well as of healthy mice and mice with experimental asthma. Wild-type mice were sensitized to ovalbumin (OVA) and exposed to an OVA aerosol in order to induce experimental allergic asthma. α-MSH was administrated intratracheally, the α-MSH antibody intraperitoneally prior each OVA challenge. Airway inflammation, cytokine production, mucus production, airway hyperresponsiveness and receptor expression were assessed. Results α-MSH levels in BAL of asthmatic individuals and mice were significantly higher compared to healthy controls. In a mouse model of experimental asthma, α-MSH neutralization increased airway inflammation and mucus production, whereas local administration of α-MSH significantly reduced inflammation of the airways. The beneficial effects were further associated with decreased levels of eosinophilic chemoattractant factors that are released by MC5R-positive T helper 2 and airway epithelial cells. Conclusion and clinical relevance α-MSH acts as a regulatory factor to maintain local immune homeostasis in allergic bronchial asthma. |
| تدمد: | 1365-2222 0954-7894 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f0dce1b8427bcedc3c469b5477ed40 https://doi.org/10.1111/cea.13400 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....19f0dce1b8427bcedc3c469b5477ed40 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652222 09547894 |
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