Anti-Nociceptive Effect and Standardization from Mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge Extracts
| العنوان: | Anti-Nociceptive Effect and Standardization from Mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge Extracts |
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| المؤلفون: | Hong-Won Suh, Set Byeol Kim, Seung Hwan Hwang, Zhiqiang Wang, Soon Sung Lim, Sang-Pil Jang |
| المصدر: | Journal of Medicinal Food. 21:596-604 |
| بيانات النشر: | Mary Ann Liebert Inc, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Gout, Medicine (miscellaneous), Salvia miltiorrhiza, Agrimonia, Gout Suppressants, Nitric oxide, Mice, 03 medical and health sciences, chemistry.chemical_compound, Animals, Humans, Anti nociceptive, Mice, Inbred ICR, Nutrition and Dietetics, Ethanol, Traditional medicine, biology, Plant Extracts, Chemistry, Macrophages, biology.organism_classification, Agrimonia pilosa, RAW 264.7 Cells, 030104 developmental biology, Gout arthritis, Icr mice |
| الوصف: | Agrimonia pilosa Ledeb has been previously reported to produce an anti-nociceptive effect in ICR mice in both tail-flick and hot-plate tests. Studies have shown that Salvia miltiorrhiza Bunge, also renowned in traditional Chinese medicine, is an effective anti-inflammatory treatment. Among the extraction solvents investigated, a 50% ethanol (EtOH) extract of A. pilosa produced the highest anti-nociceptive effect in monosodium uric acid-induced gout pain models and the greatest yield. The 80% EtOH extract of S. miltiorrhiza moderately inhibited lipopolysaccharide-induced nitric oxide release from RAW 264.7 murine macrophages and exhibited outstanding yield. The mixture of optimized A. pilosa and S. miltiorrhiza extracts were evaluated for enhanced anti-nociceptive effects in gout arthritis treatment. To control extract quality, four marker compounds were determined using an HPLC-DAD method. A 1:1 mixture of A. pilosa 50 and S. miltiorrhiza 80% EtOH extracts of produced better results than when the extracts were administered individually. |
| تدمد: | 1557-7600 1096-620X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a06b9ee792905d6ab49ace1faf51e31 https://doi.org/10.1089/jmf.2017.4077 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....1a06b9ee792905d6ab49ace1faf51e31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577600 1096620X |
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