Emergence of collective territorial defense in bacterial communities: horizontal gene transfer can stabilize microbiomes
| العنوان: | Emergence of collective territorial defense in bacterial communities: horizontal gene transfer can stabilize microbiomes |
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| المؤلفون: | Attila Kertész-Farkas, Dóra Szabó, János Juhász, Sándor Pongor |
| المصدر: | PLoS ONE PLoS ONE, Vol 9, Iss 4, p e95511 (2014) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Biophysical Simulations, Gene Transfer, Horizontal, Genotype, Biophysics, lcsh:Medicine, Gene transfer, Biology, Models, Biological, Microbiology, Host organism, Evolutionary Modeling, Genetics, Computer Simulation, Microbiome, lcsh:Science, Gene, Multidisciplinary, Resistance (ecology), Bacteria, Ecology, Microbiota, lcsh:R, Genetic Variation, Biology and Life Sciences, Computational Biology, Genomics, Antimicrobial, Metagenomics, Horizontal gene transfer, lcsh:Q, Research Article |
| الوصف: | Multispecies bacterial communities such as the microbiota of the gastrointestinal tract can be remarkably stable and resilient even though they consist of cells and species that compete for resources and also produce a large number of antimicrobial agents. Computational modeling suggests that horizontal transfer of resistance genes may greatly contribute to the formation of stable and diverse communities capable of protecting themselves with a battery of antimicrobial agents while preserving a varied metabolic repertoire of the constituent species. In other words horizontal transfer of resistance genes makes a community compatible in terms of exoproducts and capable to maintain a varied and mature metagenome. The same property may allow microbiota to protect a host organism, or if used as a microbial therapy, to purge pathogens and restore a protective environment. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a097c7b1060f385161574856504c6c1 https://pubmed.ncbi.nlm.nih.gov/24755769 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1a097c7b1060f385161574856504c6c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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