Flavone Composition and Antihypercholesterolemic and Antihyperglycemic Activities of Chrysanthemum coronarium L
| العنوان: | Flavone Composition and Antihypercholesterolemic and Antihyperglycemic Activities of Chrysanthemum coronarium L |
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| المؤلفون: | Howaida I. Abd-Alla, Hanan F. Aly, Nagwa M. M. Shalaby, Kamel H. Shaker, Marzougah A Albalawy |
| المصدر: | Zeitschrift für Naturforschung C. 69:199-208 |
| بيانات النشر: | Walter de Gruyter GmbH, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Chrysanthemum, Flavonoid, Ethyl acetate, Ether, Flavones, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Animals, Hypoglycemic Agents, Organic chemistry, Petroleum ether, Rats, Wistar, chemistry.chemical_classification, Traditional medicine, Plant Extracts, Chemistry, Anticholesteremic Agents, Glycoside, Rats, Spectrophotometry, Ultraviolet, Composition (visual arts), Methanol |
| الوصف: | Five flavones were isolated from Chrysanthemum coronarium L., four of which were isolated for the first time from the genus Chrysanthemum. Two were the flavonoid aglycones 5,7- dihydroxy-3,6,4’-trimethoxyflavone (1) and scutellarin-6,7-dimethyl ether (2). A new flavonoid glycoside, apigenin-7-O-[2’’(6’’’-O-b-ß-acetylglucopyranosyl)]-6’’-O-acetylglucopyranoside (3), along with two known ones, i. e. apigenin-7-O-(2’’-O-b-ß-glucopyranosyl)-b-ß-glucopyranoside (4) and 6-methoxy quercetin-7-O-b-ß-glucopyranoside (5), were identified. Structures were elucidated by NMR and MS. The therapeutic value of petroleum ether, ethyl acetate, and methanol extracts, respectively, in rats suffering from hypercholesterolemia - as a consequence of high-fat diet - and hyperglycemia - as a consequence of hypercholesterolemia and low doses of streptozotocin - was investigated through determination of biochemical markers and histopathology. The ethyl acetate and methanol extracts showed remarkable results, followed by the petroleum ether extract |
| تدمد: | 1865-7125 0939-5075 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1b781f79b2996292368b93c85515b1 https://doi.org/10.5560/znc.2013-0115 |
| رقم الأكسشن: | edsair.doi.dedup.....1a1b781f79b2996292368b93c85515b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18657125 09395075 |
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