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Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy

التفاصيل البيبلوغرافية
العنوان: Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy
المؤلفون: Patty Sachamitr, Paul J. Fairchild
المصدر: Expert Review of Clinical Immunology. 8:547-555
بيانات النشر: Informa UK Limited, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Autoimmune disease, Antigen Presentation, XCR1, business.industry, medicine.medical_treatment, Immunology, Antigen presentation, Cross-presentation, Dendritic Cells, Immunotherapy, medicine.disease, Cross-Priming, Immune system, Antigen, medicine, Humans, Immunology and Allergy, Cytotoxic T cell, business
الوصف: Dendritic cells (DCs) possess the specialized potential to present exogenously derived antigen to cytotoxic T lymphocytes to elicit an immune response. This process, termed cross presentation, is crucial in the generation of immune response to viruses, tumors and in autoimmune disease. The ability of DCs to cross-present exogenous antigen to cytotoxic T lymphocytes makes them an attractive target for exploitation in immunotherapy. In recent years, significant advances have been made in understanding the mechanism of cross-presentation and the DC subsets involved. The recent discovery of the human cross presenting DC has given this field a new lease of life. In this report, the authors provide an overview of cross-presentation of antigen by DCs, focusing on the current understanding of the molecular mechanisms of the process. The authors also discuss the DC subsets involved in cross presentation and its role in health and disease.
تدمد: 1744-8409
1744-666X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3f4a0d3817018a997aac644ccb8d64
https://doi.org/10.1586/eci.12.45
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....1b3f4a0d3817018a997aac644ccb8d64
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17448409
1744666X