The recombinant maize ribosome-inactivating protein transiently reduces viral load in SHIV89.6 infected Chinese Rhesus Macaques
| العنوان: | The recombinant maize ribosome-inactivating protein transiently reduces viral load in SHIV89.6 infected Chinese Rhesus Macaques |
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| المؤلفون: | Kam-Bo Wong, Wei Pang, Amanda Nga-Sze Mak, Ka-Yee Au, Sue Ka-Yee Law, Gao-Hong Zhang, Xuan Zhang, Rong-Hua Luo, Yong-Tang Zheng, Hong-Yi Zheng, Rui-Rui Wang, Liang-Min Gao, Pang-Chui Shaw, Ming-Xu Zhang |
| المصدر: | Toxins Toxins, Vol 7, Iss 1, Pp 156-169 (2015) Volume 7 Issue 1 Pages 156-169 |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Health, Toxicology and Mutagenesis, Ribosome Inactivating Proteins, Simian Acquired Immunodeficiency Syndrome, lcsh:Medicine, Toxicology, Macaque, Zea mays, Article, law.invention, Immune system, law, biology.animal, maize RIP, Protein biosynthesis, Animals, biology, Ribosome-inactivating protein, animal model, lcsh:R, Ribosomal RNA, Viral Load, anti-HIV, Virology, Macaca mulatta, Recombinant Proteins, Anti-Retroviral Agents, Recombinant DNA, Leukocytes, Mononuclear, Simian Immunodeficiency Virus, Viral load, Ex vivo |
| الوصف: | Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation loop which is proteolytically removed for full catalytic activity. Here, we showed that the recombinant active maize RIP protected chimeric simian-human immunodeficiency virus (SHIV) 89.6-infected macaque peripheral blood mononuclear cells from lysis ex vivo and transiently reduced plasma viral load in SHIV89.6-infected rhesus macaque model. No evidence of immune dysregulation and other obvious side-effects was found in the treated macaques. Our work demonstrates the potential development of maize RIP as an anti-HIV agent without impeding systemic immune functions. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6651 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b55695c2f9d94402904471e56905712 https://pubmed.ncbi.nlm.nih.gov/25606813 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1b55695c2f9d94402904471e56905712 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726651 |
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