Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes
| العنوان: | Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes |
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| المؤلفون: | Shanlin Fu, Luke Carroll, Clare L. Hawkins, David I. Pattison, Michael J. Davies, Carl H. Schiesser |
| المصدر: | Redox Biology, Vol 12, Iss, Pp 872-882 (2017) Carroll, L, Pattison, D I, Fu, S, Schiesser, C H, Davies, M J & Hawkins, C L 2017, ' Catalytic oxidant scavenging by selenium-containing compounds : Reduction of selenoxides and N-chloramines by thiols and redox enzymes ', Redox Biology, vol. 12, pp. 872-882 . https://doi.org/10.1016/j.redox.2017.04.023 Redox Biology |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, MSCO, methylselenocysteine selenoxide, GSH, reduced glutathione, Thioredoxin reductase, Clinical Biochemistry, Glutathione reductase, MPO, myeloperoxidase, DTNB, 5,5′-dithiobis-(2-nitrobenzoic acid), MsrB2, methionine sulfoxide reductase B2, Biochemistry, Antioxidants, chemistry.chemical_compound, SeTal, 1,4-anhydro-5-seleno-D-talitol, Organoselenium Compounds, Glutaredoxin, GlyCl, glycine chloramine, Trx, thioredoxin, SeMetO, selenomethionine selenoxide, Selenium Compounds, Selenomethionine, lcsh:QH301-705.5, Tau, taurine, NASMO, N-acetylselenomethionine selenoxide, lcsh:R5-920, Myeloperoxidase, GPx, glutathione peroxidase, biology, Chemistry, Chloramines, SePropO, seleno-bis-propionic acid selenoxide, Glutathione, 3. Good health, Glutathione Reductase, lcsh:Medicine (General), Oxidation-Reduction, Intracellular, Research Paper, SeMet, selenomethionine, TrxR, thioredoxin reductase, Thioredoxin-Disulfide Reductase, Hypochlorous acid, Stereochemistry, PBS, phosphate-buffered saline, ONOOH, peroxynitrous acid, SeTalO, 1,4-anhydro-5-seleno-D-talitol selenoxide, chemistry.chemical_element, N-chloramines, LysCl, N-α-acetyllysine chloramine, TCA, trichloroacetic acid, Catalysis, MsrA, methionine sulfoxide reductase A, TFA, trifluoroacetic acid, Selenium, 03 medical and health sciences, TNB, 5-thio-2-nitrobenzoic acid, Sulfhydryl Compounds, Hexoses, GSSG, oxidised glutathione, 030102 biochemistry & molecular biology, Organic Chemistry, NADPH, nicotinamide adenine dinucleotide phosphate, Kinetics, 030104 developmental biology, TauCl, taurine chloramine, lcsh:Biology (General), DTT, dithiothreitol, biology.protein, GSR, glutathione reductase, NADP |
| الوصف: | Myeloperoxidase produces strong oxidants during the immune response to destroy invading pathogens. However, these oxidants can also cause tissue damage, which contributes to the development of numerous inflammatory diseases. Selenium containing compounds, including selenomethionine (SeMet) and 1,4-anhydro-5-seleno-D-talitol (SeTal), react rapidly with different MPO-derived oxidants to form the respective selenoxides (SeMetO and SeTalO). This study investigates the susceptibility of these selenoxides to undergo reduction back to the parent compounds by intracellular reducing systems, including glutathione (GSH) and the glutathione reductase and thioredoxin reductase systems. GSH is shown to reduce SeMetO and SeTalO, with consequent formation of GSSG with apparent second order rate constants, k2, in the range 103–104 M−1 s−1. Glutathione reductase reduces both SeMetO and SeTalO at the expense of NADPH via formation of GSSG, whereas thioredoxin reductase acts only on SeMetO. The presence of SeMet and SeTal also increased the rate at which NADPH was consumed by the glutathione reductase system in the presence of N-chloramines. In contrast, the presence of SeMet and SeTal reduced the rate of NADPH consumption by the thioredoxin reductase system after addition of N-chloramines, consistent with the rapid formation of selenoxides, but only slow reduction by thioredoxin reductase. These results support a potential role of seleno compounds to act as catalytic scavengers of MPO-derived oxidants, particularly in the presence of glutathione reductase and NADPH, assuming that sufficient plasma levels of the parent selenoether can be achieved in vivo following supplementation. Graphical abstract fx1 Highlights • Selenoxides react with thiols including GSH by a two-step mechanism. • The reaction is proposed to occur via a selenosulfide intermediate. • The thioredoxin reductase system recycles selenomethionine selenoxide. • The glutathione reductase system reduces both N-chloramines and selenoxides. • Selenoxides can increase the reduction of N-chloramines by antioxidant systems. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2213-2317 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5e5218fd8874c2ffff8165ab4d70e2 http://www.sciencedirect.com/science/article/pii/S2213231717302136 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1b5e5218fd8874c2ffff8165ab4d70e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22132317 |
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