Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning
| العنوان: | Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning |
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| المؤلفون: | Yunjian Ni, Hongmei Zhou, Cheng Wu, Xiaoyan Ling, Zhipeng Zhu |
| المصدر: | Journal of International Medical Research, Vol 47 (2019) The Journal of International Medical Research |
| بيانات النشر: | SAGE Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, endocrine system, Medicine (General), Cardiac troponin, Heart Diseases, Clinical Research Reports, sevoflurane, postconditioning, Biochemistry, Sevoflurane, law.invention, R5-920, law, medicine, Cardiopulmonary bypass, polycyclic compounds, Humans, myocardial injury, Dexmedetomidine, Ischemic Postconditioning, Retrospective Studies, Cardiopulmonary Bypass, biology, troponin, business.industry, Troponin I, Biochemistry (medical), Cell Biology, General Medicine, Analgesics, Non-Narcotic, Middle Aged, Prognosis, Troponin, Cardiac surgery, Anesthesia, Anesthetics, Inhalation, Ischemic Preconditioning, Myocardial, biology.protein, cardiovascular system, Female, business, hormones, hormone substitutes, and hormone antagonists, Follow-Up Studies, medicine.drug |
| الوصف: | Objective This study was performed to determine the effect of dexmedetomidine (DEX) administration on myocardial damage in cardiac surgery with sevoflurane postconditioning. Methods We retrospectively examined all cardiac valve replacement surgeries from 1 April 2016 to 30 April 2017. Eligible patients were divided into two groups based on whether DEX was infused. DEX infusion was permitted only between intubation and the beginning of cardiopulmonary bypass (CPB). Sevoflurane was inhaled via the standard postconditioning procedure starting at aortic declamping. The cardiac troponin I (cTnI) level was measured at different time points. The postoperative outcomes and complications were also analyzed. Results One hundred patients were included in the study (DEX group, n = 53; non-DEX group, n = 47). Increased cTnI levels were significantly correlated with the New York Heart Association classification, CPB time, and DEX use. DEX use and the CPB time were potential independent factors contributing to changes in the cTnI level. The cTnI level at 6, 12, and 24 hours postoperatively was remarkably lower in the DEX than non-DEX group by 1.14, 7.83, and 5.86 ng/mL, respectively. Conclusions DEX decreased the cTnI level after CPB when sevoflurane postconditioning was used, especially at 6, 12, and 24 hours postoperatively. |
| اللغة: | English |
| تدمد: | 1473-2300 0300-0605 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c67457fac92f13291b0df17acaccc9b https://doaj.org/article/98932fe201a24bf087f81bd81b74976e |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1c67457fac92f13291b0df17acaccc9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
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