Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development
| العنوان: | Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development |
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| المؤلفون: | Chunyu Zhang, Zhanying Wu, Feifei Yuan, Zhijuan Wang, Yanli Sun, Fengchao Wang, Yanying Cui, Meijia Zhang, Hongwei Wei, Ke-Ping Xie |
| المصدر: | Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021) Cell Death & Disease |
| بيانات النشر: | Nature Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cyclin-Dependent Kinase Inhibitor p21, Male, 0301 basic medicine, Cancer Research, endocrine system, Immunology, Reproductive biology, Spermatogenesis arrest, Biology, Article, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine, Animals, Receptor, Aldehyde-Lyases, Mice, Inbred ICR, QH573-671, Kinase, Serine Endopeptidases, Leydig Cells, Cell Differentiation, Cell Biology, NPR2, Cell biology, Mice, Inbred C57BL, Germ Cells, 030104 developmental biology, medicine.anatomical_structure, Apoptosis, Infertility, 030220 oncology & carcinogenesis, Female, Proprotein Convertases, Signal transduction, Cytology, Receptors, Atrial Natriuretic Factor, Germ cell, Intracellular |
| الوصف: | Sphingosine phosphate lyase 1 (SGPL1) is a highly conserved enzyme that irreversibly degrades sphingosine-1-phosphate (S1P). Sgpl1-knockout mice fail to develop germ cells, resulting in infertility. However, the molecular mechanism remains unclear. The results of the present study showed that SGPL1 was expressed mainly in granulosa cells, Leydig cells, spermatocytes, and round spermatids. Sgpl1 deletion led to S1P accumulation in the gonads. In the ovary, S1P decreased natriuretic peptide receptor 2 (NPR2) activity in granulosa cells and inhibited early follicle growth. In the testis, S1P increased the levels of cyclin-dependent kinase inhibitor 1A (p21) and apoptosis in Leydig cells, thus resulting in spermatogenesis arrest. These results indicate that Sgpl1 deletion increases intracellular S1P levels, resulting in the arrest of female and male germ cell development via different signaling pathways. |
| اللغة: | English |
| تدمد: | 2041-4889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9f5b14c8a1b9e272ecc5057369e480 https://doaj.org/article/9e73b1ce25b14e758fd47372c76fa804 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1c9f5b14c8a1b9e272ecc5057369e480 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20414889 |
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