Ergoloids and Ischaemic Strokes; Efficacy and Mechanism of Action
| العنوان: | Ergoloids and Ischaemic Strokes; Efficacy and Mechanism of Action |
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| المؤلفون: | Azza Abbas Helmy, Maged Abdel Naseer, Fadia Elwan, Mohamed El Tamawy, I. E. Banhawy, Osamah Elwan, Ann A Abdel Kader |
| المصدر: | Journal of International Medical Research. 23:154-166 |
| بيانات النشر: | SAGE Publications, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_treatment, Statistics as Topic, Biochemistry, 050105 experimental psychology, Brain Ischemia, law.invention, Central nervous system disease, 03 medical and health sciences, Ergoloid Mesylates, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, medicine, Humans, 0501 psychology and cognitive sciences, Stroke, Aged, Aged, 80 and over, Psychomotor learning, Psychotropic Drugs, Nicergoline, Rehabilitation, business.industry, 05 social sciences, Biochemistry (medical), 030229 sport sciences, Cell Biology, General Medicine, Middle Aged, medicine.disease, Clinical trial, Treatment Outcome, Ergoloid, Anesthesia, Female, business, medicine.drug |
| الوصف: | In this double-blind, randomized study the efficacy of the ergoloid compounds, co-dergocrine mesylate and nicergoline, in the rehabilitation of patients with ischaemic stroke was investigated. A group of 30 patients was treated daily with 60 mg nicergoline, orally, and a second group of 27 patients was given 1.8 – 6 mg co-dergocrine mesylate, orally or intramuscularly, daily (depending on the time since the initial ischaemic insult) for 6 months. Outcome measures included: motoricity index (limb function); Sandoz Clinical Assessment Geriatric (SCAG) scale; psychometric tests to assess functions such as attention, psychomotor performance, perception and sensory and short-term memory; conventional and computerized electroencephalography; and P300 and reaction time measures. The results showed improvements in some aspects such as limb function ( P < 0.05), SCAG score ( P < 0.01) and some electrophysiological parameters ( P < 0.01) after treatment with both drugs. Though statistically significant most of the changes were not large. The efficacy of both drugs was qualitatively similar. The quantitative difference in some aspects in favour of nicergoline could be attributed to differences in the mechanisms of action of the two drugs, although it is also possible that the difference may reflect the dosages used. Nootropic drugs may induce a condition that facilitates the effects of cognitive training. |
| تدمد: | 1473-2300 0300-0605 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf8cd75122b2ccc10b71a57c9802d99 https://doi.org/10.1177/030006059502300302 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1cf8cd75122b2ccc10b71a57c9802d99 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
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