Exosomes and the Future of Immunotherapy in Pancreatic Cancer
| العنوان: | Exosomes and the Future of Immunotherapy in Pancreatic Cancer |
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| المؤلفون: | Inês A. Batista, Sonia A. Melo |
| المساهمون: | Instituto de Investigação e Inovação em Saúde |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 3, p 567 (2019) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | endocrine system diseases, medicine.medical_treatment, pancreatic cancer, Pancreatic Neoplasms / metabolism, Review, exosomes, Exosomes, Exosomes / metabolism, Catalysis, lcsh:Chemistry, Inorganic Chemistry, Immune system, Carcinoma, Pancreatic Ductal / therapy, Pancreatic cancer, medicine, Animals, Humans, Pancreatic Neoplasms / physiopathology, Secretion, Physical and Theoretical Chemistry, Carcinoma, Pancreatic Ductal / metabolism, lcsh:QH301-705.5, Molecular Biology, Survival rate, Spectroscopy, business.industry, Organic Chemistry, Cancer, General Medicine, Immunotherapy, medicine.disease, Carcinoma, Pancreatic Ductal / physiopathology, digestive system diseases, Microvesicles, Computer Science Applications, Pancreatic Neoplasms, Pancreatic Neoplasms / therapy, Immunotherapy / methods, lcsh:Biology (General), lcsh:QD1-999, Quality of Life, Cancer research, immunotherapy, Nanocarriers, business, Carcinoma, Pancreatic Ductal |
| الوصف: | Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, associated with a late diagnosis and a five-year survival rate of 8%. Currently available treatments fall short in improving the survival and quality of life of PDAC patients. The only possible curative option is still the surgical resection of the tumor. Exosomes are extracellular vesicles secreted by cells that transport proteins, lipids, and nucleic acids to other cells, triggering phenotypic changes in the recipient cells. Tumor cells often secrete increased amounts of exosomes. Tumor exosomes are now accepted as important players in the remodeling of PDAC tumor stroma, particularly in the establishment of an immunosuppressive microenvironment. This has sparked the interest in their usefulness as mediators of immunomodulatory effects for the treatment of PDAC. In fact, exosomes are now under study to understand their potential as nanocarriers to stimulate an immune response against cancer. This review highlights the latest findings regarding the function of exosomes in tumor-driven immunomodulation, and the challenges and advantages associated with the use of these vesicles to potentiate immunotherapy in PDAC. The laboratory is supported by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by FCT—Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Inovacao in the framework of the projects “Institute for Research and Innovation in Health Sciences” POCI-01-0145-FEDER-007274 and POCI-01-0145-FEDER-32189; and by Norte Portugal Regional Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), in the framework of the project NORTE-01-0145-FEDER-000029; and Fundacao AstraZeneca 2017 FAZ Ciencia Award. SM is supported by FCT (IF/00543/2013). |
| وصف الملف: | application/pdf |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d16e218235724bdf633310943af7e15 https://doi.org/10.3390/ijms20030567 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1d16e218235724bdf633310943af7e15 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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