التفاصيل البيبلوغرافية
العنوان:
Potent and selective xanthine-based inhibitors of phosphodiesterase 5
المؤلفون:
Robin Alec Fairhurst , Joseph D. Fullerton , David Andrew Sandham , Heinz E. Moser , Mauro Zurini , Sandra Haberthuer , Darryl Brynley Jones , Mark Dodds , Julia Hatto , Gurdip Bhalay , Colin Howes , Paul Nicklin , Simon J. Watson , David Farr , Reto Naef , Irene Muller , Andrew Dunstan , Nichola J. Arnold , Nicholas James Devereux , Morris Tweed , Angela Glen , Katharine L. Turner , Beate Leuenberger , David Beer , Sylvie Gomez , Ruth Arnold , Thomas H. Keller , Stephen Paul Collingwood , Sarah Craig
المصدر:
Bioorganic & Medicinal Chemistry Letters . 17:2376-2379
بيانات النشر:
Elsevier BV, 2007.
سنة النشر:
2007
مصطلحات موضوعية:
Male , Clinical Biochemistry , Biological Availability , Pharmaceutical Science , Biochemistry , Inhibitory Concentration 50 , Structure-Activity Relationship , chemistry.chemical_compound , Dogs , Erectile Dysfunction , 3',5'-Cyclic-GMP Phosphodiesterases , In vivo , Drug Discovery , Animals , Humans , Protein Isoforms , Structure–activity relationship , Pharmacokinetics , Enzyme Inhibitors , Molecular Biology , Cyclic Nucleotide Phosphodiesterases, Type 5 , chemistry.chemical_classification , Organic Chemistry , Biological activity , Xanthine , In vitro , Bioavailability , Enzyme , chemistry , Xanthines , cGMP-specific phosphodiesterase type 5 , Molecular Medicine , Cattle , sense organs
الوصف:
Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent inhibitors of PDE5, with good levels of selectivity against other PDE isoforms, including PDE6. Studies in the dog indicate excellent oral bioavailability for compound 21.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e21375e8e7ea71d3deb6323b8cc3fb4 https://doi.org/10.1016/j.bmcl.2006.11.019
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....1e21375e8e7ea71d3deb6323b8cc3fb4
قاعدة البيانات:
OpenAIRE
