Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations
| العنوان: | Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations |
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| المؤلفون: | Hui Wenjia, Jiajie Lu, Feng Gao, Juanli Yuan, Hongbing Chen, Jasper Engel, Jinyan Gao, Mengyu Xu, Chunyan Zhou, Zhenzhu Sun, Luud J.W.J. Gilissen |
| المصدر: | Alimentary Pharmacology and Therapeutics 51 (2020) 11 Alimentary Pharmacology and Therapeutics, 51(11), 1116-1129 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, China, medicine.medical_specialty, Adolescent, Tissue transglutaminase, Silk, Kazakh, Ethnic populations, Gastroenterology, Coeliac disease, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biopsy, Epidemiology, Ethnicity, Prevalence, Humans, Medicine, Life Science, Pharmacology (medical), 030212 general & internal medicine, Aged, Geography, Hepatology, medicine.diagnostic_test, biology, business.industry, Haplotype, nutritional and metabolic diseases, Middle Aged, medicine.disease, Confidence interval, language.human_language, Celiac Disease, Plant Breeding, Biometris, BIOS Applied Metabolic Systems, language, biology.protein, Female, 030211 gastroenterology & hepatology, business |
| الوصف: | Background: Epidemiological data of coeliac disease are lacking from the central Asian region. Aims: To verify the occurrence of coeliac disease amongst four major ethnic groups of Xinjiang Uyghur Autonomus Region, China. Methods: 2277 in-patients with gastrointestinal symptoms (1391 Han, 608 Uyghur, 146 Kazakh and 132 Hui; mean age: 54 ± 12.8 years) were included. Total IgA, anti-deamidated gliadin peptide (DGP)-IgG, and anti-tissue transglutaminase (anti-tTG)-IgA were analysed. All antibody-positive subjects were further tested for endomysial (EMA) antibodies and were HLA genotyped. All subjects with antibody positivity were asked to undergo intestinal biopsy. In addition, a subset of antibody-negative subjects were tested for HLA-DQA1and DQB1. Results: Among the 2277 subjects, 29 subjects were defined as coeliac disease au-toimmune (positive results for anti-tTG IgA and EMA-IgA) (1.27%; 95% confidence interval, 0.81%-1.73%), eight of them underwent biopsy and all showed coeliac dis-ease histology (0.35%; 95% Cl, 0.11%-0.59%). The frequency of coeliac disease au-toimmunity was lowest among the Han (0.79%), followed by the Uyghur (1.81%), the Kazakh (2.05%) and the Hui (3.03%). The frequency of the HLA-DQ2 and/or DQ8 haplotype was highest in the Uyghur (52.1%), followed by the Hui (44.4%), the Kazakh (40.0%) and the Han (39.4%). Besides, a three times higher frequency of coeliac dis-ease autoimmunity was found among rural living subjects with significantly higher wheat consumption compared to urban living subjects (3.16% vs 0.97%, P < 0.01). Conclusions: In Xinjiang, coeliac disease does occur, especially in the rural area. The HLA haplotype and environment play key roles in the development of coeliac disease. |
| وصف الملف: | application/pdf; application/octet-stream |
| اللغة: | English |
| تدمد: | 0269-2813 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8924f4d7a03089e8b810770836d8a6 https://research.wur.nl/en/publications/prevalence-of-coeliac-disease-in-northwest-china-heterogeneity-ac |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1e8924f4d7a03089e8b810770836d8a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02692813 |
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