A case-control study on factor V Leiden: an independent, gender-dependent risk factor for venous thromboembolism
| العنوان: | A case-control study on factor V Leiden: an independent, gender-dependent risk factor for venous thromboembolism |
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| المؤلفون: | Mina Farokhian, Pouria Paridar, Anahita Kalantari, Maral Soleymani, Omid Kiani Ghalesardi, Vahideh Takhviji, Afshin Davari, Kazem Zibara, Asma Maleki, Mohammadreza Tabatabaei, Seyed Esmaeil Ahmadi, Ebrahim Azizi, Sanaz Hommayoun, Abbas Khosravi |
| المصدر: | Thrombosis Journal, Vol 19, Iss 1, Pp 1-9 (2021) Thrombosis Journal |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Deep vein, Thrombophilia, Internal medicine, medicine, Factor V Leiden, APCR, Diseases of the blood and blood-forming organs, Risk factor, business.industry, Research, Case-control study, Arterial thrombosis, Hematology, medicine.disease, Thrombosis, Pulmonary embolism, medicine.anatomical_structure, Activated protein C resistance, PE, RC633-647.5, business, DVT, Venous thromboembolism |
| الوصف: | Background Activated protein C resistance (APCR) due to factor V Leiden (FVL) mutation (R506Q) is a major risk factor in patients with venous thromboembolism (VTE). The present study investigated the clinical manifestations and the risk of venous thromboembolism regarding multiple clinical, laboratory, and demographic properties in FVL patients. Material and methods A retrospective cross-sectional analysis was conducted on a total of 288 FVL patients with VTE according to APCR. In addition, 288 VET control samples, without FVL mutation, were also randomly selected. Demographic information, clinical manifestations, family and treatment history were recorded, and specific tests including t-test, chi-square and uni- and multi-variable regression tests applied. Results APCR was found to be 2.3 times significantly more likely in men (OR: 2.1, p p < 0.05). However, APCR could not be an independent risk factor for arterial thrombosis (AT) and pregnancy complications. Moreover, patients were evaluated for thrombophilia panel tests and showed significantly lower protein C and S than the control group and patients without DVT (p Conclusion FVL mutation and APCR abnormality are noticeable risk factors for VTE. Screening strategies for FVL mutation in patients undergoing surgery, oral contraceptive medication, and pregnancy cannot be recommended, but a phenotypic test for activated protein C resistance should be endorsed in patients with VTE. |
| اللغة: | English |
| تدمد: | 1477-9560 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8aac4136126d74d7717cf8d05bdf6f https://doaj.org/article/208b4d93253640ba914b75da94cc2549 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1e8aac4136126d74d7717cf8d05bdf6f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14779560 |
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