5-HT3 Receptor Antagonists for Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials
| العنوان: | 5-HT3 Receptor Antagonists for Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials |
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| المؤلفون: | Tong Wang, Li Sun, Lin-Xin Wu, Wen Wang, Liang Zhou, Chao-Bing Zhang |
| المصدر: | Clinical Drug Investigation. 36:243-253 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Lidocaine, Pain, Pharmacology, Granisetron, 5-HT3 receptor, law.invention, Ondansetron, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, 030202 anesthesiology, law, polycyclic compounds, medicine, Humans, Serotonin 5-HT3 Receptor Antagonists, heterocyclic compounds, Pharmacology (medical), 030212 general & internal medicine, Propofol, Randomized Controlled Trials as Topic, biology, business.industry, organic chemicals, musculoskeletal, neural, and ocular physiology, Palonosetron, General Medicine, nervous system, Anesthesia, Meta-analysis, Injections, Intravenous, biology.protein, business, Anesthetics, Intravenous, medicine.drug |
| الوصف: | 5-hydroxytryptamine3 (5-HT3) receptor antagonists have been commonly used to reduce propofol injection pain. The aim of this meta-analysis was to evaluate the efficacy and safety of 5-HT3 receptor antagonists in decreasing the incidence and intensity of propofol injection pain.Online databases of Pubmed, Embase and the Cochrane Central Register of Controlled Trials were searched as well as reference lists of included studies and recent reviews. Eligible randomized controlled trials (RCTs) assessing the efficacy and safety of 5-HT3 receptor antagonists for propofol injection pain were identified. The outcomes included the incidence and intensity of propofol injection pain and adverse effects. We calculated risk ratios (RR) with 95 % confidence intervals (CIs) for dichotomous data and adopted fixed or random-effects model when proper.A total of eight RCTs were included in the final analysis. Compared with the control group, 5-HT3 receptor antagonists were related to a decreasing incidence of propofol injection pain (RR 0.43, 95 % CI 0.33-0.56, P 0.05). Besides, they also effectively alleviated the severity of propofol injection pain. They significantly reduced the number of patients with moderate (RR 0.21, 95 % CI 0.15-0.30, P 0.05) and severe pain (RR 0.16, 95 % CI 0.10-0.25, P 0.05) during propofol injection. 5-HT3 receptor antagonists and lidocaine were equally effective in preventing propofol injection pain. Moreover, only one article mentioned the adverse effects of 5-HT3 receptor antagonists in two patients.Our meta-analysis indicates that 5-HT3 receptor antagonists can effectively reduce the incidence and severity of propofol injection pain. Additionally, 5-HT3 receptor antagonists may become the alternatives to lidocaine in attenuating propofol injection pain. However, evidence is still limited for the safety of 5-HT3 receptor antagonists on propofol injection pain. |
| تدمد: | 1179-1918 1173-2563 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee34f669e6c8d2ab3e8991f6b1d4f03 https://doi.org/10.1007/s40261-016-0375-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....1ee34f669e6c8d2ab3e8991f6b1d4f03 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 11791918 11732563 |
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