Scopolin Attenuates Osteoporotic Bone Loss in Ovariectomized Mice
| العنوان: | Scopolin Attenuates Osteoporotic Bone Loss in Ovariectomized Mice |
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| المؤلفون: | Chun Whan Choi, Tae Hyun Choi, Eunkuk Park, Seon-Yong Jeong, Hyun-Seok Jin, Jeonghyun Kim, Sangho Choi, Dam Huh |
| المصدر: | Nutrients Volume 12 Issue 11 Nutrients, Vol 12, Iss 3565, p 3565 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | musculoskeletal diseases, 0301 basic medicine, medicine.medical_specialty, Osteoporosis, Osteoclasts, lcsh:TX341-641, Lycii radicis cortex, Article, Bone remodeling, OVX mice, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glucosides, Bone Density, Coumarins, Osteogenesis, Osteoclast, scopolin, Internal medicine, medicine, Animals, Bone mineral, Osteoblasts, Nutrition and Dietetics, Chemistry, Cell Differentiation, Osteoblast, 3T3 Cells, medicine.disease, osteoporosis, Disease Models, Animal, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, osteoclast, osteoblast, Ovariectomized rat, Alkaline phosphatase, Female, Scopolin, lcsh:Nutrition. Foods and food supply, Drugs, Chinese Herbal, Food Science |
| الوصف: | Bone remodeling is a renewal process regulated by bone synthesis (osteoblasts) and bone destruction (osteoclasts). A previous study demonstrated that Lycii radicis cortex (LRC) extract inhibited ovariectomized (OVX)-induced bone loss in mice. This study investigated the anti-osteoporotic effects of bioactive constituent(s) from the LRC extract. The effective compound(s) were screened, and a single compound, scopolin, which acts as a phytoalexin, was chosen as a candidate component. Scopolin treatment enhanced alkaline phosphatase activity and increased mineralized nodule formation in MC3T3-E1 pre-osteoblastic cells. However, osteoclast differentiation in primary-cultured monocytes was reduced by treatment with scopolin. Consistently, scopolin treatment increased osteoblast differentiation in the co-culture of monocytes (osteoclasts) and MC3T3-E1 (osteoblast) cells. Scopolin treatment prevented bone mineral density loss in OVX-induced osteoporotic mice. These results suggest that scopolin could be a therapeutic bioactive constituent for the treatment and prevention of osteoporosis. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f117f66b9cca2826bbbf177433aae2a https://doi.org/10.3390/nu12113565 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1f117f66b9cca2826bbbf177433aae2a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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