Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys
| العنوان: | Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys |
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| المؤلفون: | Hiroshi Mori, Kazuhito Kawabata, Hiroyuki Yamada, Satoshi Nishikawa, Makoto Tanaka, Yasuaki Hashimoto, Yasutomo Nakanishi, Yasuo Ochi |
| المصدر: | International Journal of Rheumatology, Vol 2019 (2019) International Journal of Rheumatology |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, Article Subject, Immunology, Type II collagen, Arthritis, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, N-terminal telopeptide, Internal medicine, Cathepsin K, medicine, 030304 developmental biology, 0303 health sciences, business.industry, medicine.disease, Endocrinology, 030220 oncology & carcinogenesis, Concomitant, Rheumatoid arthritis, Methotrexate, lcsh:RC925-935, business, Type I collagen, Research Article, medicine.drug |
| الوصف: | We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA was induced by immunizing with bovine type II collagen. ONO-5334 (30 mg/kg/day) was orally administered once daily and MTX (10 mg/body/day) twice weekly for 9 weeks. X-ray (evaluation of joint destruction) and swelling (inflammatory) scores of proximal interphalangeal (PIP), distal interphalangeal (DIP), and metacarpophalangeal (MP) joints were evaluated. Urinary concentrations of C-terminal telopeptide of type I collagen (CTX-I) and type II collagen (CTX-II) were measured. Arthritis, accompanied by bone and cartilage destruction, was successfully induced in this collagen-induced arthritis monkey model. ONO-5334 showed no suppressive effect on joint swelling, while the joint swelling scores in the MTX and combination (ONO-5334 + MTX) groups were less than 50% compared with the control group. ONO-5334 decreased X-ray score by a mean of 64% (p |
| وصف الملف: | text/xhtml |
| تدمد: | 1687-9279 1687-9260 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2e81bc59ec91c9e19b13db6ef9e62b https://doi.org/10.1155/2019/5710340 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1f2e81bc59ec91c9e19b13db6ef9e62b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16879279 16879260 |
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