Plasma and urine pharmacokinetics of two formulations of dexamethasone in greyhound dogs
| العنوان: | Plasma and urine pharmacokinetics of two formulations of dexamethasone in greyhound dogs |
|---|---|
| المؤلفون: | Eric Li, T. H. Morris, Steven Karamatic, Stuart W. Paine, Sally Colgan, Paul Zahra |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics. 44:689-695 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology, General Veterinary, 040301 veterinary sciences, Chemistry, Sodium, 0402 animal and dairy science, chemistry.chemical_element, 04 agricultural and veterinary sciences, Urine, Phosphate, 040201 dairy & animal science, Dexamethasone, 0403 veterinary science, chemistry.chemical_compound, Dogs, Pharmacokinetics, Area Under Curve, Pharmacodynamics, medicine, Animals, Critical assessment, Hydrocortisone, medicine.drug |
| الوصف: | Dexamethasone, formulated as sodium phosphate and as phenylpropionate combined with sodium phosphate, was administered subcutaneously to six greyhounds. Plasma and urine were collected for up to 240 h and analysed with a limit of quantification (LOQ) of at least 100 pg/ml for dexamethasone. Dexamethasone, formulated as sodium phosphate, terminal half-life was 10.4 h in plasma and approximately 16 h in urine, and at 96 h, plasma hydrocortisone concentrations returned to background with dexamethasone levels around the LOQ. Dexamethasone, formulated as phenylpropionate combined with sodium phosphate, terminal half-life, was 25.6 h in plasma and approximately 26 h in urine, and at 96 h, plasma hydrocortisone concentrations returned to background with dexamethasone levels in three of the six greyhounds around the LOQ. Critical assessment of the pharmacokinetic and pharmacodynamic data indicated how it might be utilized for medication control in racing greyhounds. |
| وصف الملف: | |
| تدمد: | 1365-2885 0140-7783 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fadeb919816142853e767134f336802 https://doi.org/10.1111/jvp.12970 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1fadeb919816142853e767134f336802 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652885 01407783 |
|---|