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BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization

التفاصيل البيبلوغرافية
العنوان: BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization
المؤلفون: Guy Berchem, Valeŕie Palissot, Céline Gongora, Salwa Sebti, Laetitia K. Linares, Patrice Codogno, Nelly Pirot, Emmanuelle Liaudet-Coopman, Esther Pérez-Gracia, Sophie Pattingre, Fabienne Desmots, Chantal Bauvy, Anne Sophie Bach, Andrew V. Hubberstey, Christine Prébois
المساهمون: Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Hématologie, Immunologie et de Thérapie Cellulaire (HITC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Department of Biological Sciences [Windsor], University of Windsor [Ca], Laboratory of Experimental Hemato-Oncology [Luxembourg] (CRP-Santé), Centre de Recherche Public de la Santé, This work is supported by the Institut National de la Santé et de la Recherche Médicale (CG, PC, LKL, EL-C, and SP), by the ARC foundation (SP), La Ligue Régionale contre Le Cancer (Comités du Gard et de l’Hérault, SP), Cancéropole Grand Sud-Ouest (SP), and the CHEMORES consortium (Tumour Chemotherapy Resistance EU FP6 to EL-C). SS has fellowships from the Fond National de la Recherche Luxembourg (FNR Luxembourg) and La Ligue Nationale contre le Cancer., Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Pontchaillou [Rennes], Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Recherche en Informatique Fondamentale (IRIF (UMR_8243)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Signalisation et physiopathologie des cellules épithéliales, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Experimental Hemato-Oncology (CRP-Santé), Centre de Recherche Public-Santé, UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Nowak, Cécile
المصدر: Autophagy
Autophagy, Taylor & Francis, 2014, 10 (7), pp.1341-1342. ⟨10.4161/auto.28979⟩
Autophagy, Taylor & Francis, 2014, 10 (7), pp.1341--2. ⟨10.4161/auto.28979⟩
Autophagy, 2014, 10 (7), pp.1341--2. ⟨10.4161/auto.28979⟩
Biological Sciences Publications
سنة النشر: 2014
مصطلحات موضوعية: p53, [SDV]Life Sciences [q-bio], animal diseases, Intracellular Space, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], E1A-Associated p300 Protein/*metabolism, Mice, Models, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Gene expression, Nuclear protein, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, Life Sciences, Nuclear Proteins, Acetylation, Cell biology, Protein Transport, Intracellular Space/*metabolism, ATG5, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, BAG3, Models, Biological, Molecular Chaperones/*metabolism, [SDV.CAN] Life Sciences [q-bio]/Cancer, Nuclear Proteins/*metabolism, BAT3, Autophagy, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Molecular Biology, Tumor Suppressor Protein p53/metabolism, Cell Biology, Biological, Molecular biology, Autophagic Punctum, ATG, Cytoplasm, Tumor Suppressor Protein p53, E1A-Associated p300 Protein, Nuclear localization sequence, nucleocytoplasmic shuttling, Molecular Chaperones
الوصف: International audience; We recently reported that BAG6/BAT3 (BCL2-associated athanogene 6) is essential for basal and starvation-induced autophagy in E18.5 bag6(-/-) mouse embryos and in mouse embryonic fibroblasts (MEFs) through the modulation of the EP300/p300-dependent acetylation of TRP53 and autophagy-related (ATG) proteins. We observed that BAG6 increases TRP53 acetylation during starvation and pro-autophagic TRP53-target gene expression. BAG6 also decreases the EP300 dependent-acetylation of ATG5, ATG7, and LC3-I, posttranslational modifications that inhibit autophagy. In addition, in the absence of BAG6 or when using a mutant of BAG6 exclusively located in the cytoplasm, autophagy is inhibited, ATG7 is hyperacetylated, TRP53 acetylation is abrogated, and EP300 accumulates in the cytoplasm indicating that BAG6 is involved in the regulation of the nuclear localization of EP300. We also reported that the interaction between BAG6 and EP300 occurs in the cytoplasm rather than the nucleus. Moreover, during starvation, EP300 is transported to the nucleus in a BAG6-dependent manner. We concluded that BAG6 regulates autophagy by controlling the localization of EP300 and its accessibility to nuclear (TRP53) and cytoplasmic (ATGs) substrates.
وصف الملف: application/pdf
تدمد: 1554-8635
1554-8627
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb112c0207cedcc4b7d8637e3f50229
https://pubmed.ncbi.nlm.nih.gov/24852146
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....1fb112c0207cedcc4b7d8637e3f50229
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15548635
15548627